Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)

被引：28

作者：

Harneti, Desi ^{[1
]}

Tjokronegoro, Roekmiati ^{[1
]}

Safari, Agus ^{[1
]}

Supratman, Unang ^{[1
]}

Loong, Xe-Min ^{[2
]}

Mukhtar, Mat Ropi ^{[2
]}

Mohamad, Khalit ^{[2
]}

Awang, Khalijah ^{[2
]}

Hayashi, Hideo ^{[3
]}

机构：

[1] Padjadjaran State Univ, Dept Chem, Fac Math & Nat Sci, Jatinangor 45363, Indonesia

[2] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 59100, Malaysia

[3] Osaka Prefecture Univ, Div Appl Life Sci, Grad Sch Life & Environm Sci, Sakai, Osaka 5998531, Japan

来源：

PHYTOCHEMISTRY LETTERS | 2012年 / 5卷 / 03期

关键词：

Aglinone; Aglinin E; Dammarane triterpenoid; Aglaia smithii; Cytotoxic activity;

D O I：

10.1016/j.phytol.2012.04.013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new dammarane triterpenoids, aglinone (1) and aglinin E (20S,24S-epoxy-25-hydroxy-1-endammarene) (2) along with three known compounds, 3-epiocotillol (3), aglinin A (4), and eichlerianic acid (5), were isolated from the bark of Aglaia smithii. The chemical structures of the new compound were elucidated on the basis of spectroscopic data interpretation. All the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1, 2, 4 and 5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 21, 42, 34, and 11 mu g/mL, respectively. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

引用

页码：496 / 499

页数：4

共 13 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] Bisamides, lignans, triterpenes, and insecticidal cyclopenta[b]benzofurans from Aglaia species [J].

Brader, G ;

Vajrodaya, S ;

Greger, H ;

Bacher, M ;

Kalchhauser, H ;

Hofer, O .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (12) :1482-1490

[3]

Heyne K., 1982, The Useful Indonesian Plants Research and Development, P1029

[4] Pregnanes and triterpenoid hydroperoxides from the leaves of Aglaia grandis [J].

Inada, A ;

Murata, H ;

Inatomi, Y ;

Nakanishi, T ;

Darnaedi, D .

PHYTOCHEMISTRY, 1997, 45 (06) :1225-1228

[5] INSECTICIDAL 1H-CYCLOPENTATETRAHYDRO[B]BENZOFURANS FROM AGLAIA-ODORATA [J].

ISHIBASHI, F ;

SATASOOK, C ;

ISMAN, MB ;

TOWERS, GHN .

PHYTOCHEMISTRY, 1993, 32 (02) :307-310

[6]

Khalit M., 1999, PHYTOCHEMISTRY, V51, P1031

[7]

Mabberley D.J., 1995, Meliceae Flora, V12, P1

[8] An insecticidal rocaglamide derivatives and related compounds from Aglaia adorata (Meliaceae) [J].

Nugroho, BW ;

Edrada, RA ;

Wray, V ;

Witte, L ;

Bringmann, G ;

Gehling, M ;

Proksch, P .

PHYTOCHEMISTRY, 1999, 51 (03) :367-376

[9] Foveolins A and B, dammarane triterpenes from Aglaia foveolata [J].

Roux, D ;

Martin, MT ;

Adeline, MT ;

Sevenet, T ;

Hadi, AHA ;

Pais, M .

PHYTOCHEMISTRY, 1998, 49 (06) :1745-1748

[10]

Sahidin, 2005, Z NATURFORSCH C, V60, P723

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