Functional roles of endogenous D-serine in the chronic pain-induced plasticity of NMDAR-mediated synaptic transmission in the central amygdala of mice

被引：4

作者：

Maekawa, Masao ^{[1
]}

Wakamatsu, Shou ^{[1
]}

Huse, Nozomi ^{[1
]}

Konno, Ryuichi ^{[2
]}

Hori, Yuuichi ^{[1
]}

机构：

[1] Dokkyo Med Univ, Sch Med, Dept Physiol & Biol Informat, Mibu, Tochigi 3210293, Japan

[2] Int Univ Hlth & Welf, Ctr Med Sci, Ohtawara, Tochigi 3248501, Japan

来源：

NEUROSCIENCE LETTERS | 2012年 / 520卷 / 01期

关键词：

Serine racemase knockout mice; D-Serine; NMDAR mediated synaptic current; Amygdala; Chronic pain; PERIPHERAL-NERVE INJURY; RECEPTORS; NEURONS; RAT; PHOSPHORYLATION;

D O I：

10.1016/j.neulet.2012.05.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The amygdala is implicated in chronic pain-induced emotional changes. Chronic pain induces plastic changes of the N-methyl-D-aspartate receptor (NMDAR) functions in the brain including the amygdala. D-Serine is synthesized endogenously by serine racemase and modulates NMDAR-mediated synaptic transmission as a coagonist of glycine binding site. To clarify the functional roles of endogenous D-serine in chronic pain-induced plasticity of NMDAR mediated synaptic transmission, we investigated the NMDAR-mediated excitatory synaptic current (EPSC) of neurons in the latero-capsular division of the central amygdala (CeLC) using brain slices from serine racemase knockout (SR-KO) mice with chronic pain induced by monoarthritis. The decay time of NMDAR-mediated EPSC was significantly elongated by monoarthritis in wild type (WT) mice, but not in SR-KO mice. The D-serine application-induced increase of NMDAR-mediated EPSC was significantly facilitated by monoarthritis in WT mice, but not in SR-KO mice. These results suggest that endogenous D-serine facilitates chronic pain-induced plastic changes of NMDAR mediated synaptic transmission in CeLC. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：57 / 61

页数：5

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