Nocardicyclins A and B: New anthracycline antibiotics produced by Nocardia pseudobrasiliensis

被引：34
作者：
Tanaka, Y
Grafe, U
Yazawa, K
Mikami, Y
Ritzau, M
机构：
[1] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CHUO KU,CHIBA 260,JAPAN
[2] HANS KNOLL INST NAT PROD RES EV,D-07745 JENA,GERMANY
来源：
JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 10期
关键词：
D O I：
10.7164/antibiotics.50.822
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nocardicyclins A (1) and B (2), new anthracycline antibiotics have been isolated from the mycelial cake of Nocardia pseudobrasiliensis IFM 0624 (JCM 9894). The molecular formulae of 1 and 2 have been determined as C30H35NO11 and C32H37NO12, respectively, and the structures were characterized by 1- and 8-methoxyl groups, a 10-carbonyl group and a novel carbon-methylated aminosugar constituent. Nocardicyclin A (1) exerts cytotoxic activity against L1210 and P388 leukemia. Nocardicyclins A (1) and B (2) are active against Gram-positive bacteria including Mycobacterium spp. and Nocardia spp., but inactive against Gram-negative bacteria.
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页码：822 / 827
页数：6
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