PET scan in clinically suspected paraneoplastic neurological syndromes: a 6-year prospective study in a regional neuroscience unit

被引:38
作者
Hadjivassiliou, M. [1 ]
Alder, S. J. [2 ]
Van Beek, E. J. R. [3 ]
Hanney, M. B. [4 ]
Lorenz, E. [5 ]
Rao, D. G. [6 ]
Sharrack, B. [1 ]
Tindale, W. B. [4 ]
机构
[1] NHS Trust, Sheffield Teaching Hosp, Royal Hallamshire Hosp, Dept Neurol, Sheffield S10 2JF, S Yorkshire, England
[2] NHS Trust, Plymouth Hosp, Dept Neurol, Plymouth, Devon, England
[3] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA
[4] NHS Trust, Sheffield Teaching Hosp, Royal Hallamshire Hosp, Dept Nucl Med, Sheffield S10 2JF, S Yorkshire, England
[5] NHS Trust, Sheffield Teaching Hosp, Royal Hallamshire Hosp, Dept Radiol, Sheffield S10 2JF, S Yorkshire, England
[6] NHS Trust, Sheffield Teaching Hosp, Royal Hallamshire Hosp, Dept Neurophysiol, Sheffield S10 2JF, S Yorkshire, England
来源
ACTA NEUROLOGICA SCANDINAVICA | 2009年 / 119卷 / 03期
关键词
immunology; neuro-oncology; paraneoplastic disorders; PET; POSITRON-EMISSION-TOMOGRAPHY; F-18; FLUORODEOXYGLUCOSE; GAMMA-CAMERA; DIAGNOSIS; CANCER; TUMORS; FDG;
D O I
10.1111/j.1600-0404.2008.01089.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The role of PET in the diagnosis of paraneoplastic neurological syndromes (PNS) has previously been reported in retrospective studies, from specialized neuro-oncology units, often selecting patients with positive paraneoplastic antibodies. To prospectively assess the usefulness of PET in detecting malignancy in patients clinically suspected of having PNS. PET was performed in patients suspected of PNS within 4 weeks of the normal CT body scan. All patients were followed up. Eighty patients suspected of having PNS underwent PET. 18/80 (23%) were abnormal and suspicious of malignancy. The total number of definite and probable PNS with abnormal PET was 11/18 (61%). The total number of definite and probable PNS with a normal PET was 3/62 (5%). Only 50% of patients with biopsy-proven malignancy were positive for paraneoplastic antibodies. The prevalence of abnormal PET in patients presenting with classical PNS was 41% as opposed to 21% in patients with non-classical PNS. The sensitivity and specificity of PET in diagnosing PNS was 75% and 87% respectively. PET is a valuable tool in clinically suspected PNS. Its use should not be restricted to specialized neuro-oncology units or in patients with positive paraneoplastic antibodies. Positive yield is the highest amongst patients with classical PNS.
引用
收藏
页码:186 / 193
页数:8
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