The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression

被引：334

作者：

Umansky, Viktor ^{[1
,2
]}

Blattner, Carolin ^{[1
,2
]}

Gebhardt, Christoffer ^{[1
,2
]}

Utikal, Jochen ^{[1
,2
]}

机构：

[1] German Canc Res Ctr, Skin Canc Unit, D-69120 Heidelberg, Germany

[2] Ruprecht Karl Univ Heidelberg, Univ Med Ctr Mannheim, Dept Dermatol Venereol & Allergol, D-68167 Mannheim, Germany

来源：

VACCINES | 2016年 / 4卷 / 04期

关键词：

myeloid-derived suppressor cells; myelopoiesis; tumor microenvironment; immunosuppression; therapeutic targeting; TRANS-RETINOIC ACID; INDUCED IMMUNE SUPPRESSION; TUMOR-BEARING HOSTS; REGULATORY T-CELLS; CHRONIC INFLAMMATION; GROWTH-FACTOR; NITRIC-OXIDE; ANTITUMOR IMMUNITY; INTERFERON-GAMMA; PROGENITOR CELLS;

D O I：

10.3390/vaccines4040036

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunosuppressive tumor microenvironment represents not only one of the key factors stimulating tumor progression but also a strong obstacle for efficient tumor immunotherapy. Immunosuppression was found to be associated with chronic inflammatory mediators including cytokines, chemokines and growth factors produced by cancer and stroma cells. Long-term intensive production of these factors induces the formation of myeloid-derived suppressor cells (MDSCs) representing one of the most important players mediating immunosuppression. Moreover, MDSCs could not only inhibit anti-tumor immune reactions but also directly stimulate tumor growth and metastasis. Therefore, understanding the mechanisms of their generation, expansion, recruitment and activation is required for the development of novel strategies for tumor immunotherapy.

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页数：16

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