The comparison of immune-enhancing activity of sulfated polysaccharidses from Tremella and Condonpsis pilosula

被引：77
作者：
Zhao, Xiaona [1 ,2 ]
Hu, Yuanliang [1 ]
Wang, Deyun [1 ]
Liu, Jianzhu [2 ]
Guo, Liwei [3 ]
机构：
[1] Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China
[2] Shandong Agr Univ, Coll Anim Sci & Vet Med, Tai An 271018, Shandong, Peoples R China
[3] Yangtze Univ, Coll Anim Sci, Jinzhou 434023, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2013年 / 98卷 / 01期
关键词：
Tremella polysaccharide (TPS); Condonpsis pilosula polysaccharide (CPPS); Sulfation modification; Lymphocyte proliferation; Antibody titer; CELLULAR INFECTIVITY; NEWCASTLE-DISEASE; ADJUVANTICITY; EXPRESSION; MODIFIERS; VACCINE;
D O I：
10.1016/j.carbpol.2013.06.043
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Based on our previous research, four sulfated polysaccharide (sPSs) from Tremella and Condonpsis pilosula, sTPS(tp), sTPS(70c), sCPPS(tp) and sCPPS(50c), were prepared and their effects on splenic lymphocytes proliferation in vitro and the immune response of ND vaccine in chicken were compared taking the unmodified polysaccharide (uPS)TPStp as control. The results showed that four sPSs could significantly or numerically stimulate splenic lymphocyte proliferation singly or synergistically with LPS in vitro, sTPS(70c) and sCPPS(tp) demonstrated better effect; promote peripheral lymphocytes proliferation and enhance serum HI antibody titer in chickens vaccinated with ND vaccine, the actions of sPSs were stronger than that of uPS, and sTPS(70c) at medium dosage presented the best efficacy. These indicated that sulfation modification could improve the immune-enhancing activity of TPS and CPPS, sTPS(70c) possessed the strongest activity and would be expected as a component of new-type immunopotentiator. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：438 / 443
页数：6
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