Cytotoxic constituents from the stem bark of Diospyros cuneata Standl.

被引：5
作者：
Quintal-Novelo, C. [1 ]
Moo-Puc, R. E. [2 ]
Chale-Dzul, J. [2 ]
Caceres-Farfan, M. [1 ]
Mendez-Gonzalez, M. [1 ]
Borges-Argaez, R. [1 ]
机构：
[1] Ctr Invest Cient Yucatan, Merida 97200, Yucatan, Mexico
[2] Inst Mexicano Seguro Social, Ctr Med Ignacio Garcia Tellez, Unidad Invest Med, Merida 97150, Yucatan, Mexico
来源：
NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 17期
关键词：
Diospyros cuneata; naphthoquinone; MTT assay; cytotoxicity; PLUMBAGIN; APOPTOSIS; CELLS;
D O I：
10.1080/14786419.2012.738201
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A phytochemical investigation of the stem bark of Diospyros cuneata (Ebenaceae) together with invitro cytotoxic evaluation of the pure compounds in four human cancer cell lines KB, Hep-2, HeLa and SiHa led to the isolation of plumbagin, elliptinone, lupeol, atraric acid methyl ester, maritinone, betulin and betulinaldehyde. The structural determination of the compounds was established by nuclear magnetic resonance, electron ionisation mass spectrometric analysis as well as comparison with data from the literature. Plumbagin exhibited a potent cytotoxic activity (CC50=3.56 mu gmL(-1)) against KB cell lines whereas maritinone displayed cytotoxic activity against Hep-2 (CC50=17.30 mu gmL(-1)), cervical cancer (CC50=21.10 mu gmL(-1)) and the KB cell lines (CC50=20.30 mu gmL(-1)). This is the first report on a phytochemical and biological evaluation of D. cuneata.
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收藏
页码：1594 / 1597
页数：4
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