The role of cardiorenal biomarkers for risk stratification in the early follow-up after hospitalisation for acute heart failure

被引：2

作者：

Tolonen, J. ^{[1
]}

Lassus, J. P. E. ^{[2
]}

Siirila-Waris, K. ^{[1
]}

Tarvasmaki, T. ^{[1
]}

Pulkki, K. ^{[3
]}

Sund, R. ^{[4
]}

Peuhkurinen, K. ^{[5
]}

Nieminen, M. S. ^{[2
]}

Harjola, V. -P. ^{[1
]}

机构：

[1] Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland

[2] Univ Helsinki, Cent Hosp, Heart & Lung Ctr, Helsinki, Finland

[3] Islab, Kuopio, Finland

[4] Natl Inst Hlth & Welf, Helsinki, Finland

[5] Oulu Deaconess Med Ctr, Oulu, Finland

来源：

BIOMARKERS | 2013年 / 18卷 / 06期

关键词：

Acute heart failure; NT-proBNP; risk stratification; troponin; BRAIN NATRIURETIC PEPTIDE; PROGNOSTIC VALUE; RENAL-FUNCTION; NT-PROBNP; CARDIAC TROPONIN; CYSTATIN-C; OUTCOMES; BNP; MORTALITY; PREDICTORS;

D O I：

10.3109/1354750X.2013.821522

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context Cardiorenal biomarkers (CBs) predict outcome in acute heart failure (AHF). Objective: To evaluate CBs in early follow-up prognostication. Methods: In 124 AHF patients, levels of CystatinC, NT-proBNP and Troponinl measured five weeks from admission (W5) and relative change from day 2 (D2) were assessed for 6-month prognosis (mortality/HF hospitalization). Results: The combined end-point occurred in 33 patients (27%). D2-, W5-cystatin >= median, and lack of >= 30%decrease in NT-proBNP were independent predictors of outcome. Additionally, a risk score established from W5 CBs identified patients with very high event rate. Conclusions: CBs at early follow-up of AHF may guide risk stratification.

引用

页码：525 / 531

页数：7

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