Simple and rapid determination of the drug naproxen in pharmaceutical preparations by heavy atom-induced room temperature phosphorescence

被引：32

作者：

Carretero, AS ^{[1
]}

Cruces-Blanco, C ^{[1
]}

García, MIR ^{[1
]}

Díaz, BC ^{[1
]}

Gutiérrez, AF ^{[1
]}

机构：

[1] Univ Granada, Dept Analyt Chem, Fac Sci, E-18071 Granada, Spain

来源：

TALANTA | 1999年 / 50卷 / 02期

关键词：

heavy atom induced; naproxen; room temperature phosphorescence;

D O I：

10.1016/S0039-9140(99)00126-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple, selective and sensitive heavy atom-induced room temperature phosphorimetric method (HAI-RTP) is described for the determination of naproxen (NAP) in pharmaceutical preparations. The phosphorescence signals are a consequence of intermolecular protection when analytes are, exclusively, in presence of a heavy atom salt and sodium sulfite as an oxygen scavenger to minimize RTP quenching. These variables selection constitute the basis of a HAI-RTP method for the determination of naproxen (detection limit 17.6 ng ml(-1); 1.71% relative standard deviation at 250 ng ml(-1)). The method has been applied satisfactorily to the analysis of pharmaceutical preparations. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：401 / 407

页数：7