Synthesis of Dienyl Ketones via Palladium(II)-Catalyzed Direct Cross-Coupling Reactions between Simple Alkenes and Vinyl Ketones: Application to the Synthesis of Vitamin A1 and Bornelone

被引：19

作者：

Zhang, Xiang ^{[1
,2
]}

Wang, Min ^{[1
,2
]}

Zhang, Ming-Xin ^{[1
,2
]}

Xu, Yun-He ^{[1
,2
]}

Loh, Teck-Peng ^{[1
,2
,3
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[3] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 21期

基金：

美国国家科学基金会; 中国博士后科学基金;

关键词：

C-H BONDS; STEREOCONTROLLED SYNTHESIS; STEREOSPECIFIC SYNTHESIS; OLEFINATION REACTION; EFFICIENT SYNTHESIS; SELECTIVE ACCESS; MONOTERPENES; ACRYLATES; ESTERS; ACID;

D O I：

10.1021/ol402692t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and general method for the synthesis of conjugated dienyl ketones via palladium(II) acetate catalyzed direct cross-coupling between simple alkenes and vinyl ketones is reported. This method has been successfully applied for the synthesis of Vitamin A1 and bornelone.

引用

页码：5531 / 5533

页数：3