In the borderland of multifocal motor neuropathy and chronic inflammatory demyelinating polyradiculopathy

被引:2
作者
Topakian, Raffi [1 ]
Mueller, Petra [1 ]
Ciovica-Oel, Ioana-Cristina [2 ]
Trenkler, Johannes [3 ]
机构
[1] Acad Teaching Hosp Wels Grieskirchen, Dept Neurol, Grieskirchner Str 42, A-4600 Wels, Austria
[2] Kepler Univ Hosp, Dept Neurol, Linz, Austria
[3] Kepler Univ Hosp, Inst Neuroradiol, Linz, Austria
关键词
Cerebrospinal fluid protein; Chronic inflammatory demyelinating polyradiculopathy; Differential diagnosis; Magnetic resonance imaging; Multifocal motor neuropathy; Nerve conduction studies; Overlap; SOCIETIES/PERIPHERAL NERVE SOCIETY; JOINT TASK-FORCE; NEUROLOGICAL SOCIETIES; EUROPEAN FEDERATION; GUIDELINE;
D O I
10.1007/s10072-020-04804-9
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Chronic inflammatory demyelinating polyradiculopathy (CIDP) and multifocal motor neuropathy (MMN) are seen as distinct entities with marked differences in pathophysiology and clinical, laboratory, and imaging features. We report a patient with an immune-mediated neuropathy in the borderland of CIDP and MMN, whose magnetic resonance imaging and cerebrospinal fluid (CSF) features strongly resembled CIDP, while the clinical course and treatment response suggested the diagnosis of MMN without conduction blocks. There is strong evidence that MMN is not a variant of CIDP and that these conditions can be separated pathologically. Our case report widens the spectrum of MMN presentations, indicating the existence of a clinical overlap syndrome of MMN and CIDP, and emphasizing the need for more precise criteria regarding CSF and nerve root imaging abnormalities in the differentiation of chronic immune-mediated neuropathies.
引用
收藏
页码:1131 / 1134
页数:4
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