Efficacy of Crest Herbal Toothpaste in "Clearing Internal Heat": A Randomized, Double-Blind Clinical Study

被引:1
作者
Chen, Jia-Xu [1 ]
Liu, Yue-Yun [1 ]
Wang, Shao-Xian [1 ]
Li, Xiao-Hong [1 ]
机构
[1] Beijing Univ Chinese Med, Sch Preclin Med, Beijing 100029, Peoples R China
关键词
D O I
10.1155/2013/807801
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Objective. Evaluation of the efficacy of Crest Herbal Crystal Toothpaste in "clearing internal heat." Methods. This was a randomized, double-blind, controlled parallel design clinical test of a product that was already on the market. 72 subjects were randomly assigned to control group (group A with Colgate Herbal Salty Toothpaste) or treatment group (group B with Crest Herbal Crystal Toothpaste) with ratio of 1:2. Subjects were instructed to brush with 1g toothpaste for 2 minutes each time, 2 times per day in a 4-a week test period; measurement with the rating scale on the efficacy of "clearing internal heat" for the herbal toothpaste was done at baseline, 2 weeks, and 4 weeks of toothpaste usage. Results. The rating scale on efficacy of "clearing internal heat" for the herbal toothpaste reveals that the primitive points of 72-case intention-to-treat (ITT) analysis and 67-case per-protocol (PP) analysis for subjects in group A and subjects in group B were found to be reduced progressively with statistical significance (P < 0.05). The overall effective rates for group A and group B were, respectively, 62.50%, 56.25% (ITT) and 62.50%, 60.64% (PP). The statistical results indicated that the symptoms of fire-heat for both groups of subjects have been improved after application of toothpaste. Conclusion. The efficacy of Crest Herbal Crystal Toothpaste in "clearing internal heat" was confirmed by the trial as compared to Colgate Herbal Salty Toothpaste. And its efficacy was objectively evaluated by the rating scale on efficacy of "clearing internal heat."
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页数:7
相关论文
共 8 条
[1]  
[Anonymous], PHARM PEOPL REP CHIN
[2]  
Chen H., 2007, CHIN J MICROECO CHIN, V19, P352
[3]  
Chen J. X., 2011, DIAGNOSTICS CHINESE
[4]  
Pei X., 2001, J MOD ORAL MED CHIN, V15, P151
[5]  
Poyato-Ferrera M, 2003, Int J Dent Hyg, V1, P110, DOI 10.1034/j.1601-5037.2003.00018.x
[6]  
Yang L., 1999, CHIN J MED HIST CHIN, V29, P121
[7]   Development and evaluation of Chinese medicine fire-heat syndrome scale in oral cavity for measuring Chinese herb toothpaste [J].
Zhao Hui ;
Wang Shao-xian ;
Li Xiao-hong ;
Chen Jia-xu .
CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2013, 19 (03) :192-199
[8]  
Zheng X. Y., 2002, GUIDING PRINCIPLES N, V105