Limited granulomatosis with polyangiitis in an adolescent with Crohn's disease on infliximab therapy: cause or coincidence?

被引：3

作者：

Arora, Harbir ^{[1
]}

Madani, Shailender ^{[2
]}

Debelenko, Larisa V. ^{[3
]}

McGrath, Eric J. ^{[1
]}

Mutyala, Ramakrishna ^{[4
]}

Guglani, Lokesh ^{[5
]}

机构：

[1] Childrens Hosp Michigan, Carman & Ann Adams Dept Pediat, Div Pediat Infect Dis, Detroit, MI 48201 USA

[2] Childrens Hosp Michigan, Carman & Ann Adams Dept Pediat, Div Pediat Gastroenterol, Detroit, MI 48201 USA

[3] Wayne State Univ, Childrens Hosp Michigan, Sch Med, Div Pediat Pathol, Detroit, MI USA

[4] Childrens Hosp Michigan, Carman & Ann Adams Dept Pediat, Div Pediat Hospitalist Med, Detroit, MI 48201 USA

[5] Childrens Hosp Michigan, Carman & Ann Adams Dept Pediat, Div Pediat Pulm Med, Detroit, MI 48201 USA

来源：

CLINICAL RESPIRATORY JOURNAL | 2015年 / 9卷 / 04期

关键词：

adverse effects; Crohn's disease; granuloma; inflammatory bowel disease; infliximab; lung biopsy; lung disease; pulmonary nodules; tumor necrosis factor; LUNG-DISEASE; WEGENERS-GRANULOMATOSIS; AUTOIMMUNE-DISEASES; PATIENT;

D O I：

10.1111/crj.12168

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pulmonary involvement in Crohn's disease (CD) may precede the development of intestinal inflammation, but in most cases occurs during the course of treatment, either as an extra-intestinal manifestation, because of secondary infections, or as a side effect of the therapy itself. This case highlights the differential diagnosis and work up for multiple pulmonary nodules that developed in a patient with CD who had been in remission on infliximab therapy. Even though infectious causes, such as Mycobacteria and Fungi, account for majority of these cases, the possibility of non-infectious conditions such as autoimmune disorders should also be considered.

引用

页码：506 / 511

页数：6

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