A Comparison of Extracellular Excitatory Amino Acids Release Inhibition of Acute Lamotrigine and Topiramate Treatment in the Hippocampus of PTZ-kindled Epileptic Rats

被引：128

作者：

Deng, Yan ^{[1
,3
]}

Wang, Minghuan ^{[2
]}

Jiang, Li ^{[2
]}

Ma, Chao ^{[1
]}

Xi, Zhijiang ^{[1
]}

Li, Xiaolong ^{[1
,3
]}

He, Nongyue ^{[1
,3
]}

机构：

[1] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China

[2] Southeast Univ, Sch Clin Med, Nanjing 210009, Peoples R China

[3] Hunan Univ Technol, Hunan Key Lab Green Packaging & Applicat Biol Nan, Zhuzhou 412007, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2013年 / 9卷 / 06期

基金：

中国博士后科学基金;

关键词：

Lamotrigine (LTG); Topiramate (TPM); Epilepsy; Excitatory Amino Acid (EAA); Comparison; MAGNETIC NANOPARTICLES; GLUTAMATE RELEASE; NMDA RECEPTORS; ADD-ON; ANTICONVULSANT; AMPLIFICATION; CARBAMAZEPINE; MECHANISMS; ASPARTATE; ISCHEMIA;

D O I：

10.1166/jbn.2013.1599

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this communication, the effect of acute treatment with lamotrigine (LTG) and topiramate (TPM) was investigated on release of the main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-kindled freely moving rats using microdialysis. The results showed that the level of Glu and Asp significantly decreased in the PTZ-kindled epileptic (EP) rat hippocampus after the 20 mg/kg LTG or 40 mg/kg TPM administration. But LTG gave rise to a better result than TPM in controlling EAA release.

引用

页码：1123 / 1128

页数：6

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