The clinical utility of sperm DNA integrity testing

被引:39
作者
不详
机构
[1] Amer Soc Reprod Med, Birmingham, AL USA
关键词
D O I
10.1016/j.fertnstert.2008.08.054
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Sperm DNA damage is more common in infertile men and may contribute to poor reproductive performance. However, current methods for evaluating sperm DNA integrity do not reliably predict treatment outcomes, and no treatment for abnormal DNA integrity has proven clinical value. (Fertil Steril (R) 2008;90:S178-80. (C)2008 by American Society for Reproductive Medicine.)
引用
收藏
页码:S178 / S180
页数:3
相关论文
共 38 条
  • [1] Ahmadi A, 1999, J EXP ZOOL, V284, P696, DOI 10.1002/(SICI)1097-010X(19991101)284:6&lt
  • [2] 696::AID-JEZ11&gt
  • [3] 3.0.CO
  • [4] 2-E
  • [5] Susceptibility of human sperm to in situ DNA denaturation is strongly correlated with DNA strand breaks identified by single-cell electrophoresis
    Aravindan, GR
    Bjordahl, J
    Jost, LK
    Evenson, DP
    [J]. EXPERIMENTAL CELL RESEARCH, 1997, 236 (01) : 231 - 237
  • [6] A MODEL FOR THE STRUCTURE OF CHROMATIN IN MAMMALIAN SPERM
    BALHORN, R
    [J]. JOURNAL OF CELL BIOLOGY, 1982, 93 (02) : 298 - 305
  • [7] Impact of a mild scrotal heat stress on DNA integrity in murine spermatozoa
    Banks, S
    King, SA
    Irvine, DS
    Saunders, PTK
    [J]. REPRODUCTION, 2005, 129 (04) : 505 - 514
  • [8] Association of cyclophosphamide-induced male-mediated, foetal abnormalities with reduced paternal germ-cell apoptosis
    Brinkworth, MH
    Nieschlag, E
    [J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2000, 447 (02) : 149 - 154
  • [9] The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI
    Bungum, M
    Humaidan, P
    Spano, M
    Jepson, K
    Bungum, L
    Giwercman, A
    [J]. HUMAN REPRODUCTION, 2004, 19 (06) : 1401 - 1408
  • [10] Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss
    Carrell, DT
    Liu, L
    Peterson, CM
    Jones, KP
    Hatasaka, HH
    Erickson, L
    Campbell, B
    [J]. ARCHIVES OF ANDROLOGY, 2003, 49 (01): : 49 - 55