On-Demand Drug Release System for InVivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

被引：191

作者：

Lee, Jae-Hyun ^{[1
]}

Chen, Kuan-Ju ^{[2
]}

Noh, Seung-Hyun ^{[1
]}

Garcia, Mitch Andre ^{[2
]}

Wang, Hao ^{[2
,3
]}

Lin, Wei-Yu ^{[2
,4
]}

Jeong, Heeyeong ^{[1
]}

Kong, Brian Junoh ^{[2
]}

Stout, David B. ^{[2
]}

Cheon, Jinwoo ^{[1
]}

Tseng, Hsian-Rong ^{[2
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

[2] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, CIMI, Calif NanoSyst Inst CNSI,Inst Mol Med IMED, Los Angeles, CA 90095 USA

[3] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[4] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 80708, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 16期

关键词：

drug delivery; magnetic heat induction; magnetic nanoparticles; molecular imaging; supramolecular chemistry; IRON-OXIDE NANOPARTICLES; DELIVERY; DOXORUBICIN; THERAPEUTICS; ACCUMULATION; ABSORPTION; LIPOSOMES; ACTUATION; DESIGN; TUMORS;

D O I：

10.1002/anie.201207721

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On-demand drug release: Magnetothermally responsive drug-encapsulated supramolecular nanoparticles for on-demand drug release in vivo have been developed. The remote application of an alternative magnetic field heats the magnetic particles that effectively trigger the release of the drug. An acute drug concentration can be delivered to the tumor in vivo, resulting in an improved therapeutic outcome. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4384 / 4388

页数：5

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