Cleavable linkers for porous silicon-based mass spectrometry

被引：43
作者：
Meng, JC
Averbuj, C
Lewis, WG
Siuzdak, G
Finn, MG
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 10期
关键词：
cleavage reactions; combinatorial chemistry; lipases; mass spectrometry; porous silicon;
D O I：
10.1002/anie.200352803
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dip, wash, and analyze: Molecules can be attached to tailored porous silicon wafers by using Diels-Alder reactions and efficiently detached and detected in the laser pulse of a MALDI mass spectrometer in a positionally encoded manner (see scheme).
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页码：1255 / 1260
页数：6
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