Epstein-Barr virus encephalitis in a renal transplant recipient manifesting as hemorrhagic, ring-enhancing mass lesions

被引：12

作者：

Babik, J. M. ^{[1
]}

Katrak, S. ^{[1
]}

Miller, S. ^{[2
]}

Shah, M. ^{[3
]}

Chin-Hong, P. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Div Infect Dis, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2015年 / 17卷 / 05期

关键词：

Epstein-Barr virus; encephalitis; renal transplant; immunocompromise; primary central nervous system lymphoma; post-transplant lymphoproliferative disorder; ganciclovir; valganciclovir; CENTRAL-NERVOUS-SYSTEM; POLYMERASE-CHAIN-REACTION; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; STEM-CELL TRANSPLANTATION; CEREBROSPINAL-FLUID; PREDICTIVE-VALUE; VIRAL LOAD; DIAGNOSIS; DISEASES; INFECTIONS;

D O I：

10.1111/tid.12431

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein-Barr virus (EBV) encephalitis has been infrequently described in immunocompromised patients. Here, we report a unique case of biopsy-proven EBV encephalitis in a renal transplant recipient presenting with altered mental status, prominent visual disturbances, and hemorrhagic, ring-enhancing mass lesions on magnetic resonance imaging. The patient was successfully treated with a prolonged course of antivirals. This case illustrates the difficulty in interpretation of cerebrospinal fluid EBV polymerase chain reaction assay, given the lack of specificity in immunocompromised patients.

引用

页码：744 / 750

页数：7

共 37 条

[21] Epstein-Barr virus encephalitis presenting with a tumor-like lesion in an immunosuppressed transplant recipient [J].

Khalil, Michael ;

Enzinger, Christian ;

Wallner-Blazek, Mirja ;

Scarpatetti, Michael ;

Barth, Alain ;

Horn, Sabine ;

Reiter, Gudrun .

JOURNAL OF NEUROVIROLOGY, 2008, 14 (06) :574-578

[22] Isolated cerebral manifestation of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: a case of clinical and diagnostic challenges [J].

Kittan, N. A. ;

Beier, F. ;

Kurz, K. ;

Niller, H. H. ;

Egger, L. ;

Jilg, W. ;

Andreesen, R. ;

Holler, E. ;

Hildebrandt, G. C. .

TRANSPLANT INFECTIOUS DISEASE, 2011, 13 (05) :524-530

[23] Epstein-Barr virus encephalitis after kidney transplantation and successful treatment with brivudine [J].

Lahmer, Tobias ;

Hoffmann, Dieter ;

Heemann, Uwe ;

Kuechle, Claudius ;

Frank, Helga .

TRANSPLANT INTERNATIONAL, 2010, 23 (06) :e24-e25

[24] Primary central nervous system post-transplant lymphoproliferative disorders following allogeneic hematopoietic stem cell transplantation [J].

Lieberman, Frank ;

Yazbeck, Victor ;

Raptis, Anastasios ;

Felgar, Raymond ;

Boyiadzis, Michael .

JOURNAL OF NEURO-ONCOLOGY, 2012, 107 (02) :225-232

[25] Epstein-Barr virus encephalitis in a renal allograft recipient diagnosed by polymerase chain reaction on cerebrospinal fluid and successfully treated with ganciclovir [J].

MacGinley, R ;

Bartley, PB ;

Sloots, T ;

Johnson, DW .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (01) :197-198

[26] Clinical characteristics of patients with Epstein Barr virus in cerebrospinal fluid [J].

Martelius, Timi ;

Lappalainen, Maija ;

Palomaki, Maarit ;

Anttila, Veli-Jukka .

BMC INFECTIOUS DISEASES, 2011, 11

[27] Suspected immune reconstitution inflammatory syndrome associated with the proliferation of Kaposi's sarcoma during HAART [J].

Nathan, Ramesh V. .

AIDS, 2007, 21 (06) :775-775

[28] Cerebral vasculitis and encephalitis due to Epstein-Barr virus in a patient with newly diagnosed HIV infection [J].

Raman, Lavanya ;

Nelson, Mark .

JOURNAL OF CLINICAL VIROLOGY, 2014, 59 (04) :264-267

[29] Discrepancy in EBV-DNA load between peripheral blood and cerebrospinal fluid in a patient with isolated CNS post-transplant lymphoproliferative disorder [J].

Shimizu, Hiroaki ;

Saitoh, Takayuki ;

Koya, Hiroko ;

Yuzuriha, Akinori ;

Hoshino, Takumi ;

Hatsumi, Nahoko ;

Takada, Satoru ;

Nagaki, Tomohito ;

Nojima, Yoshihisa ;

Sakura, Toru .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2011, 94 (05) :495-498

[30] Molecular Diagnosis of Central Nervous System Opportunistic Infections in HIV-Infected Zambian Adults [J].

Siddiqi, Omar K. ;

Ghebremichael, Musie ;

Dang, Xin ;

Atadzhanov, Masharip ;

Kaonga, Patrick ;

Khoury, Michael N. ;

Koralnik, Igor J. .

CLINICAL INFECTIOUS DISEASES, 2014, 58 (12) :1771-1777

← 1 2 3 4 →