Epstein-Barr virus encephalitis in a renal transplant recipient manifesting as hemorrhagic, ring-enhancing mass lesions

被引：12
作者：
Babik, J. M. [1 ]
Katrak, S. [1 ]
Miller, S. [2 ]
Shah, M. [3 ]
Chin-Hong, P. [1 ]
机构：
[1] Univ Calif San Francisco, Div Infect Dis, Dept Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
来源：
TRANSPLANT INFECTIOUS DISEASE | 2015年 / 17卷 / 05期
关键词：
Epstein-Barr virus; encephalitis; renal transplant; immunocompromise; primary central nervous system lymphoma; post-transplant lymphoproliferative disorder; ganciclovir; valganciclovir; CENTRAL-NERVOUS-SYSTEM; POLYMERASE-CHAIN-REACTION; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; STEM-CELL TRANSPLANTATION; CEREBROSPINAL-FLUID; PREDICTIVE-VALUE; VIRAL LOAD; DIAGNOSIS; DISEASES; INFECTIONS;
D O I：
10.1111/tid.12431
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Epstein-Barr virus (EBV) encephalitis has been infrequently described in immunocompromised patients. Here, we report a unique case of biopsy-proven EBV encephalitis in a renal transplant recipient presenting with altered mental status, prominent visual disturbances, and hemorrhagic, ring-enhancing mass lesions on magnetic resonance imaging. The patient was successfully treated with a prolonged course of antivirals. This case illustrates the difficulty in interpretation of cerebrospinal fluid EBV polymerase chain reaction assay, given the lack of specificity in immunocompromised patients.
引用
收藏
页码：744 / 750
页数：7
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