Epstein-Barr virus encephalitis in a renal transplant recipient manifesting as hemorrhagic, ring-enhancing mass lesions

被引：12

作者：

Babik, J. M. ^{[1
]}

Katrak, S. ^{[1
]}

Miller, S. ^{[2
]}

Shah, M. ^{[3
]}

Chin-Hong, P. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Div Infect Dis, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2015年 / 17卷 / 05期

关键词：

Epstein-Barr virus; encephalitis; renal transplant; immunocompromise; primary central nervous system lymphoma; post-transplant lymphoproliferative disorder; ganciclovir; valganciclovir; CENTRAL-NERVOUS-SYSTEM; POLYMERASE-CHAIN-REACTION; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; STEM-CELL TRANSPLANTATION; CEREBROSPINAL-FLUID; PREDICTIVE-VALUE; VIRAL LOAD; DIAGNOSIS; DISEASES; INFECTIONS;

D O I：

10.1111/tid.12431

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein-Barr virus (EBV) encephalitis has been infrequently described in immunocompromised patients. Here, we report a unique case of biopsy-proven EBV encephalitis in a renal transplant recipient presenting with altered mental status, prominent visual disturbances, and hemorrhagic, ring-enhancing mass lesions on magnetic resonance imaging. The patient was successfully treated with a prolonged course of antivirals. This case illustrates the difficulty in interpretation of cerebrospinal fluid EBV polymerase chain reaction assay, given the lack of specificity in immunocompromised patients.

引用

页码：744 / 750

页数：7

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