Architectural and Functional Commonalities between Enhancers and Promoters

被引：230
作者：
Kim, Tae-Kyung [1 ]
Shiekhattar, Ramin [2 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA
[2] Univ Miami, Dept Human Genet, Sylvester Comprehens Canc Ctr, Miller Sch Med, Miami, FL 33136 USA
来源：
CELL | 2015年 / 162卷 / 05期
基金：
美国国家科学基金会;
关键词：
RNA-POLYMERASE-II; IMMUNOGLOBULIN HEAVY-CHAIN; LONG NONCODING RNAS; BETA-GLOBIN GENE; SUPER-ENHANCERS; HS2; ENHANCER; U1; SNRNP; TRANSCRIPTIONAL PROMOTERS; INTERGENIC TRANSCRIPTION; CHROMATIN LANDSCAPE;
D O I：
10.1016/j.cell.2015.08.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.
引用
收藏
页码：948 / 959
页数：12
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