Irreversible electroporation (IRE) is a predominantly nonthermal ablative technology that uses high-voltage, low-energy DC current pulses to induce cell death. Thermal ablative technologies such as radiofrequency ablation, microwave ablation, and cryoablation have several applications in oncology but have limitations that have been established. IRE has shown promise to overcome some of these limitations. This article reviews the basics of the technology, patient selection, clinical applications, practical pointers, and the published data.
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Tan Tock Seng Hosp, Dept Diagnost Radiol, 11 Jalan Tan Tock Seng, Singapore 308433, SingaporeTan Tock Seng Hosp, Dept Diagnost Radiol, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
Chan, Gabriel
Pua, Uei
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Tan Tock Seng Hosp, Dept Diagnost Radiol, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, SingaporeTan Tock Seng Hosp, Dept Diagnost Radiol, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
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Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Univ Paris Sud, UMR 8121, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Al-Sakere, Bassim
Andre, Franck
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Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Univ Paris Sud, UMR 8121, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Andre, Franck
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Bernat, Claire
Connault, Elisabeth
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Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Univ Paris Sud, UMR 8121, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Connault, Elisabeth
Opolon, Paule
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Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Univ Paris Sud, UMR 8121, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Opolon, Paule
Davalos, Rafael V.
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Virginia Tech Wake Forest Univ, Sch Biomed Engn & Sci, Blacksburg, VA USAInst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Davalos, Rafael V.
Rubinsky, Boris
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Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
Univ Calif Berkeley, Grad Program Biophys, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA
Hebrew Univ Jerusalem, Sch Comp Sci & Engn, Ctr Bioengn Serv Humanity & Soc, Jerusalem, IsraelInst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Rubinsky, Boris
Mir, Lluis M.
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Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France
Univ Paris Sud, UMR 8121, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8121, Villejuif, France