Whole-genome association studies of complex diseases

被引：4
|
作者：
Sham, Pak C. [1 ,2 ,3 ]
Cherny, Stacey S. [1 ,2 ]
Kao, Patrick Y. P. [4 ]
Song, You-Qiang [3 ,4 ]
Chan, Danny [3 ,4 ]
Cheung, Kenneth M. C. [3 ,5 ]
机构：
[1] Univ Hong Kong, Dept Psychiat, Pokfulam, Hong Kong, Peoples R China
[2] Univ Hong Kong, Genome Res Ctr, Pokfulam, Hong Kong, Peoples R China
[3] Univ Hong Kong, Ctr Reprod Growth & Dev, Pokfulam, Hong Kong, Peoples R China
[4] Univ Hong Kong, Dept Biochem, Pokfulam, Hong Kong, Peoples R China
[5] Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulam, Hong Kong, Peoples R China
来源：
CURRENT ORTHOPAEDICS | 2008年 / 22卷 / 04期
基金：
美国国家卫生研究院;
关键词：
genome-wide association; GWA; whole genome association; WGA; single nucleotide polymorphism; SNP;
D O I：
10.1016/j.cuor.2008.05.006
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Understanding how the variable co-action and interaction of multiple genetic and environmental factors lead to disease occurrence may lead to novel. prevention and intervention strategies. Whole-genome association (WGA) or genome-wide association (GWA) promises to determine the genetic contribution to variability in disease risk. This review is an overview of the principles of WGA and its limitations. Some essential concepts and terminology are explained. (C) 2008 Elsevier Ltd. All. rights reserved.
引用
收藏
页码：251 / 258
页数：8
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