Utilization of chitosan-caged liposomes to push the boundaries of therapeutic delivery

被引：64

作者：

Alavi, Sonia ^{[1
]}

Haeri, Azadeh ^{[1
]}

Dadashzadeh, Simin ^{[1
,2
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut, POB 14155-6153, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran

来源：

CARBOHYDRATE POLYMERS | 2017年 / 157卷

关键词：

Liposomes; Chitosan; Chitosan derivatives; Administration routes; Mucoadhesion; N-TRIMETHYL CHITOSAN; IN-VITRO EVALUATION; DRUG ABSORPTION ENHANCEMENT; SURFACE-MODIFIED LIPOSOMES; ORAL PEPTIDE DELIVERY; COATED LIPOSOMES; CARBOXYMETHYL CHITOSAN; LOADED LIPOSOMES; NASAL DELIVERY; PHYSICOCHEMICAL PROPERTIES;

D O I：

10.1016/j.carbpol.2016.10.063

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Liposomes are self-assembled bilayer vesicles which have attracted a great deal of interest as potential carriers for a wide range of therapeutic agents. They have significantly decreased toxicity of drugs while improving or at least maintaining their efficacy. However, their further development has been hampered by their considerable instabilities and, in some cases, providing comparable efficacy to conventional products. Decoration of liposomal nanocarriers with chitosan (CS) and its derivatives has recently gained importance to overcome this obstacle. CS, a cationic polysaccharide, has prompted the continuous impetus for the advent of efficient drug delivery systems owing to its unique characteristics. CS decoration of liposomes confers high mucoadhesion capacity, enhanced carrier permeability, and sterically stabilized properties. The number of examples having been explained within the present review through different administration routes and for various applications clearly heralds the promise of CS caged liposomes for the pharmaceutical market. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：991 / 1012

页数：22

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