Iron-catalyzed hydroxylation of β-ketoesters with hydrogen peroxide as oxidant

被引：47

作者：

Li, Dongmei ^{[1
]}

Schroeder, Kristin ^{[1
]}

Bitterlich, Bianca ^{[1
]}

Tse, Man Kin ^{[1
,2
]}

Beller, Matthias ^{[1
,2
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

[2] Univ Rostock, Ctr Life Sci Automat, D-18119 Rostock, Germany

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 41期

关键词：

iron catalysis; selective oxidation; ketoester; hydrogen peroxide;

D O I：

10.1016/j.tetlet.2008.07.157

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hydroxylation of beta-ketoesters was studied using simple iron catalysts and 30 wt % hydrogen peroxide as the terminal oxidant. The highest activity and yield were achieved in the presence of iron(III) chloride. Cyclic beta-ketoesters could be smoothly hydroxylated in 75-90% yield. For linear beta-ketoester and beta-ketoamide, the chloro-substituted products were obtained. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5976 / 5979

页数：4

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