What is the significance of a significant TDT?

被引：14

作者：

Ewens, WJ ^{[1
]}

Spielman, RS

机构：

[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

来源：

HUMAN HEREDITY | 2005年 / 60卷 / 04期

关键词：

TDT; linkage; association; haplotype relative risk; hypothesis testing; validity; linkage disequilibrium;

D O I：

10.1159/000090544

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This note summarizes the development of the transmission/ disequilibrium test ( TDT). The initial purpose of the TDT procedure was to test for linkage between a genetic marker and a disease susceptibility locus when an association had been found between the two. An association between disease and marker had sometimes been taken to imply linkage. An association could, however, be due to population stratification even in the absence of linkage. In contrast, the outcome of the TDT is not affected by such stratification. Furthermore, when linkage is not in doubt, the TDT can, in some cases, also provide a test of association between marker and disease. We discuss these various matters in this paper.

引用

页码：206 / 210

页数：5

共 17 条

[1] THE INSULIN GENE AND SUSCEPTIBILITY TO IDDM [J].