New natural barrigenol-like triterpenoid isolated from the husks of Xanthoceras sorbifolia Bunge

被引：22
|
作者：
Wang, Da [1 ]
Yu, Bin [2 ]
Chen, Chuming [3 ]
Duan, Jie [2 ]
Di, Donghua [1 ]
Xiong, Xin [2 ]
Yang, Yiren [2 ]
Gao, Huiyuan [2 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Liaoning, Peoples R China
[3] Dalian Amer Int Sch Grade 11, Dalian, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 09期
关键词：
Xanthoceras sorbifolia Bunge; 16-deoxybarringtogenol C; carbohydrate chain; cytotoxicity; SAPONINS; EXTRACT; ESCIN;
D O I：
10.1080/14786419.2017.1375916
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The Xanthoceras sorbifolia Bunge husks were known for their abundant triterpenoids resource, which contributed to many bioactivities, such as antitumor, antiinflammatory and neuroprotection. The present study has led to the purification of a new triterpenoid saponin, 21-O-acetyl-xanthohuskiside A (1), together with six known barrigenol derivatives (2-7), whose structures were authenticated on the basis of NMR, HR-MS, IR spectrum and acid hydrolysis experiment. Compound 7 showed more noteworthy cytotoxicity towards three human tumour cell lines (HCT-116, HepG-2 and U87-MG) than other compounds. [GRAPHICS] .
引用
收藏
页码：997 / 1003
页数：7
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