Immune-mediated Neuropathy with Anti-disialosyl IgM Antibodies in Diffuse Large B-cell Lymphoma: A Case Report and Literature Review

被引：5

作者：

Shihashi, Gen ^{[1
]}

Yagi, Takuya ^{[1
]}

Suzuki, Shigeaki ^{[1
]}

Seki, Morinobu ^{[1
]}

Kohashi, Sumiko ^{[2
]}

Ueda, Tomoki ^{[2
]}

Kameyama, Kaori ^{[3
]}

Kusunoki, Susumu ^{[4
]}

Nakajima, Hideaki ^{[2
]}

Okamoto, Shinichiro ^{[2
]}

Suzuki, Norihiro ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Neurol, Tokyo 108, Japan

[2] Keio Univ, Sch Med, Dept Med, Div Hematol, Tokyo 108, Japan

[3] Keio Univ, Sch Med, Dept Pathol, Tokyo 108, Japan

[4] Kinki Univ, Sch Med, Dept Neurol, Higashiosaka, Osaka 577, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 13期

关键词：

Guillain-Barre syndrome; malignant lymphoma; immune-mediated neuropathy; anti-ganglioside antibody; paraneoplastic syndrome; diffuse large B-cell lymphoma; MONOCLONAL IGM; POLYNEUROPATHY; GANGLIOSIDES; FEATURES; PATIENT;

D O I：

10.2169/internalmedicine.54.4451

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). He was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and received high-dose intravenous immunoglobulin for the treatment of neuropathy. After initiating the treatments, the patient's neurological impairment improved dramatically. He currently remains in complete remission without a flare-up of the polyneuropathy. Based upon our experience and other case reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we conclude that determining the anti-ganglioside antibody profile and beginning early treatment should be considered promptly for patients with malignant lymphoma who develop polyneuropathy.

引用

页码：1647 / 1651

页数：5

共 16 条

[1] Antiganglioside antibodies in paraneoplastic peripheral neuropathies [J].