Paraoxonase 1 Status in Keratoconus: A Preliminary Study of Activity and Polymorphism

被引:0
作者
Poh, R. [1 ]
Tan, J. A. M. A. [1 ]
Deva, J. P. [2 ]
Poo, D. [1 ]
Yong, Y. [1 ]
Arjunan, S. [1 ]
机构
[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia
[2] Tun Hussein Onn Natl Eye Hosp, Petaling Jaya, Selangor, Malaysia
关键词
Genotype; keratoconus; oxidative stress; paraoxonase; 1; OXIDATIVE STRESS; PON1; EXPRESSION; PHENOTYPE; GENOTYPE; DISEASE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To determine the activity of paraoxonase 1 (PON1) in keratoconus in a Malaysian population in comparison with non-keratoconic subjects. Methods: Clinical eye examinations were performed on patients with keratoconus and non-keratoconic subjects after questionnaires were completed. Blood samples were collected and subjected to spectro-photometric analysis of paraoxonase and diazoxonase activities for the determination of the status of PON1 of every individual. Results: Of the 11 keratoconic patients and 55 non-keratoconic control samples collected, eight patients of Indian ethnicity were keratoconic (73%), whereas 33 non-Indians were non-keratoconic (60%; p = 0.047). Paraoxonase activity was lower in Indians compared to the non-Indians ie Malays and Chinese (p = 0.008). Keratoconic subjects had a lower paraoxonase activity compared to non-keratoconics (p = 0.038). Conclusions: The reduced paraoxonase activity in keratoconic patients suggests that the keratoconic corneas were more susceptible to oxidative stress. Reduced paraoxonase activity and keratoconus status appears to be associated with ethnicity.
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页码:569 / 573
页数:5
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