The complex link between severity of asthma and rhinitis in mite allergic patients

被引：11
作者：
Antonicelli, Leonardo [1 ]
Braschi, Maria Chiara [1 ]
Bresciani, Megon [2 ]
Bonifazi, Martina [1 ]
Baldacci, Sandra [2 ]
Angino, Anna [2 ]
Pala, Anna Paola [2 ]
Viegi, Giovanni [3 ]
机构：
[1] Azienda Osped Univ Osped Riuniti, Allergy Unit, Dept Immunoallerg & Resp Dis, Ancona, Italy
[2] CNR, Inst Clin Physiol, Pulm Environm Epidemiol Unit, I-56100 Pisa, Italy
[3] CNR, Inst Biomed & Mol Immunol, Palermo, Italy
来源：
RESPIRATORY MEDICINE | 2013年 / 107卷 / 01期
关键词：
Asthma; Comorbidity; Mite hypersensitivity; Rhinitis; Severity; EXHALED NITRIC-OXIDE; RHINOSINUSITIS; CLASSIFICATION; ASSOCIATION; COEXISTENCE; PREVALENCE; SYMPTOMS; AIRWAYS; ONSET;
D O I：
10.1016/j.rmed.2012.09.023
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: The aim of the study was to evaluate the link between the severity of upper and lower airways diseases in mite allergic patients with respiratory allergy. Patients and method: A multicentre, observational, cross-sectional study was carried out in 556 consecutively enrolled mite allergic patients with rhinitis and asthma comorbidity attending a specialist unit. Severity assessment of rhinitis and asthma was evaluated in accordance with ARIA and GINA guidelines. Results: Reliable data were available for 518 patients. The distribution of rhinitis severity was: 15.6% mild intermittent rhinitis, 4.4% moderate-severe intermittent rhinitis, 30.3% mild persistent rhinitis and 49.6% moderate persistent rhinitis. The distribution of asthma severity was: 41.3% mild intermittent asthma, 14.3% mild persistent asthma, 19.1% moderate persistent asthma and 25.3% severe persistent asthma. In patients with moderate-severe persistent rhinitis (49.5%) a significant trend (p = 0.005) was found pointing to an increased link with asthma severity. Conclusion: A link between respective severities of rhinitis and asthma was found in only half of mite allergic patients with rhinitis and asthma. (c) 2012 Elsevier Ltd. All rights reserved.
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页码：23 / 29
页数：7
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