T memory stem cells in health and disease

被引：456

作者：

Gattinoni, Luca ^{[1
]}

Speiser, Daniel E. ^{[2
]}

Lichterfeld, Mathias ^{[3
]}

Bonini, Chiara ^{[4
,5
]}

机构：

[1] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] Univ Lausanne Hosp, Ludwig Canc Res, Dept Oncol, Lausanne, Switzerland

[3] Harvard Med Sch, Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA

[4] Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Expt Hematol Unit, Leukemia Unit, Milan, Italy

[5] Univ Vita Salute San Raffaele, Hematol Dept, Milan, Italy

来源：

NATURE MEDICINE | 2017年 / 23卷 / 01期

基金：

美国国家卫生研究院; 欧盟第七框架计划; 瑞士国家科学基金会;

关键词：

YELLOW-FEVER; BONE-MARROW; B-CELL; ANTIRETROVIRAL THERAPY; LINEAGE RELATIONSHIP; PROTECTIVE IMMUNITY; CUTTING EDGE; SELF-RENEWAL; HOMEOSTATIC PROLIFERATION; ANTITUMOR-ACTIVITY;

D O I：

10.1038/nm.4241

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

T memory stem (TscM) cells are a rare subset of memory lymphocytes endowed with the stem cell like ability to self-renew and the multipotent capacity to reconstitute the entire spectrum of memory and effector T cell subsets. Cumulative evidence in mice, nonhuman primates and humans indicates that Tscm cells are minimally differentiated cells at the apex of the hierarchical system of memory T lymphocytes. Here we describe emerging findings demonstrating that Tscm cells, owing to their extreme longevity and robust potential for immune reconstitution, are central players in many physiological and pathological human processes. We also discuss how Tscm cell stemness could be leveraged therapeutically to enhance the efficacy of vaccines and adoptive T cell therapies for cancer and infectious diseases or, conversely, how it could be disrupted to treat Tscm cell driven and sustained diseases, such as autoimmunity, adult T cell leukemia and HIV-1.

引用

页码：18 / 27

页数：10

共 158 条

[91] T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate [J].

Mackay, Laura K. ;

Wynne-Jones, Erica ;

Freestone, David ;

Pellicci, Daniel G. ;

Mielke, Lisa A. ;

Newman, Dane M. ;

Braun, Asolina ;

Masson, Frederick ;

Kallies, Axel ;

Belz, Gabrielle T. ;

Carbone, Francis R. .

IMMUNITY, 2015, 43 (06) :1101-1111

[92] Genome-wide RNA profiling of long-lasting stem cell-like memory CD8 T cells induced by Yellow Fever vaccination in humans [J].

Marraco, Silvia A. Fuertes ;

Soneson, Charlotte ;

Delorenzi, Mauro ;

Speiser, Daniel E. .

GENOMICS DATA, 2015, 5 :297-301

[93] Long-lasting stem cell-like memory CD8+ T cells with a naive-like profile upon yellow fever vaccination [J].

Marraco, Silvia A. Fuertes ;

Soneson, Charlotte ;

Cagnon, Laurene ;

Gannon, Philippe O. ;

Allard, Mathilde ;

Maillard, Samia Abed ;

Montandon, Nicole ;

Rufer, Nathalie ;

Waldvogel, Sophie ;

Delorenzi, Mauro ;

Speiser, Daniel E. .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (282)

[94] Low Frequency of Circulating CD8+ T Stem Cell Memory Cells in Chronic Chagasic Patients with Severe Forms of the Disease [J].

Mateus, Jose ;

Lasso, Paola ;

Pavia, Paula ;

Rosas, Fernando ;

Roa, Nubia ;

Andres Valencia-Hernandez, Carlos ;

Mario Gonzalez, John ;

Puerta, Concepcion J. ;

Cuellar, Adriana .

PLOS NEGLECTED TROPICAL DISEASES, 2015, 9 (01)

[95] Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia [J].

Maude, Shannon L. ;

Frey, Noelle ;

Shaw, Pamela A. ;

Aplenc, Richard ;

Barrett, David M. ;

Bunin, Nancy J. ;

Chew, Anne ;

Gonzalez, Vanessa E. ;

Zheng, Zhaohui ;

Lacey, Simon F. ;

Mahnke, Yolanda D. ;

Melenhorst, Jan J. ;

Rheingold, Susan R. ;

Shen, Angela ;

Teachey, David T. ;

Levine, Bruce L. ;

June, Carl H. ;

Porter, David L. ;

Grupp, Stephan A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (16) :1507-1517

[96] Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells [J].

Mazo, IB ;

Honczarenko, M ;

Leung, H ;

Cavanagh, LL ;

Bonasio, R ;

Weninger, W ;

Engelke, K ;

Xia, LJ ;

McEver, RP ;

Koni, PA ;

Silberstein, LE ;

von Andrian, UH .

IMMUNITY, 2005, 22 (02) :259-270

[97] Therapeutic vaccines for cancer: an overview of clinical trials [J].

Melero, Ignacio ;

Gaudemack, Gustav ;

Gerritsen, Winald ;

Huber, Christoph ;

Parmiani, Giorgio ;

Scholl, Suzy ;

Thatcher, Nicholas ;

Wagstaff, John ;

Zielinski, Christoph ;

Faulkner, Ian ;

Mellstedt, Hakan .

NATURE REVIEWS CLINICAL ONCOLOGY, 2014, 11 (09) :509-524

[98] Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines [J].

Miller, Joseph D. ;

van der Most, Robbert G. ;

Akondy, Rama S. ;

Glidewell, John T. ;

Albott, Sophia ;

Masopust, David ;

Murali-Krishna, Kaja ;

Mahar, Patryce L. ;

Edupuganti, Srilatha ;

Lalor, Susan ;

Germon, Stephanie ;

Del Rio, Carlos ;

Mulligan, Mark J. ;

Staprans, Silvija I. ;

Altman, John D. ;

Feinberg, Mark B. ;

Ahmed, Rafi .

IMMUNITY, 2008, 28 (05) :710-722

[99] Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life [J].

Morrison, Sean J. ;

Spradling, Allan C. .

CELL, 2008, 132 (04) :598-611

[100] T memory stem cells are the hierarchical apex of adult T-cell leukemia [J].

Nagai, Yuya ;

Kawahara, Masahiro ;

Hishizawa, Masakatsu ;

Shimazu, Yayoi ;

Sugino, Noriko ;

Fujii, Sumie ;

Kadowaki, Norimitsu ;

Takaori-Kondo, Akifumi .

BLOOD, 2015, 125 (23) :3527-3535

← 5 6 7 8 9 10 11 12 13 14 →