New Frontiers in the Design and Synthesis of Imaging Probes for PET Oncology: Current Challenges and Future Directions

被引：30
作者：
Smith, Graham [2 ]
Carroll, Laurence [1 ]
Aboagye, Eric O. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Comprehens Canc Imaging Ctr, Fac Med, London W12 0NN, England
[2] Univ Hull, Postgrad Med Inst, Kingston Upon Hull HU6 7RX, N Humberside, England
来源：
MOLECULAR IMAGING AND BIOLOGY | 2012年 / 14卷 / 06期
关键词：
Positron emission tomography; Probe development; Therapy monitoring; F-18]FDG; COPPER-FREE CLICK; IN-VITRO; POSITRON; APOPTOSIS; CANCER; HYPOXIA; PROLIFERATION; THERAPY; TUMORS; TRACER;
D O I：
10.1007/s11307-012-0590-y
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Despite being developed over 30 years ago, 2-deoxy-2-[F-18]fluoro-d-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.
引用
收藏
页码：653 / 666
页数：14
相关论文
共 92 条
[41]   Altered Tissue 3′-Deoxy-3′-[18F]Fluorothymidine Pharmacokinetics in Human Breast Cancer following Capecitabine Treatment Detected by Positron Emission Tomography [J].
Kenny, Laura M. ;
Contractor, Kaiyumars B. ;
Stebbing, Justin ;
Ai-Nahhas, Adil ;
Palmieri, Carlo ;
Shousha, Sami ;
Coombes, R. Charles ;
Aboagye, Eric O. .
CLINICAL CANCER RESEARCH, 2009, 15 (21) :6649-6657
[42]   Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [64Cu]-ATSM, [99mTc]-HL91 and [18F]-FMISO Tumor Hypoxia Accumulation [J].
Kersemans, Veerle ;
Cornelissen, Bart ;
Hueting, Rebekka ;
Tredwell, Matthew ;
Hussien, Kamila ;
Allen, Philip D. ;
Falzone, Nadia ;
Hill, Sally A. ;
Dilworth, Jonathan R. ;
Gouverneur, Veronique ;
Muschel, Ruth J. ;
Smart, Sean C. .
PLOS ONE, 2011, 6 (11)
[43]   Synthesis of [18F]-Labeled (6-Fluorohexyl)triphenylphosphonium Cation as a Potential Agent for Myocardial imaging using Positron Emission Tomography [J].
Kim, Dong-Yeon ;
Kim, Hee-Jung ;
Yu, Kook-Hyun ;
Min, Jung-Joon .
BIOCONJUGATE CHEMISTRY, 2012, 23 (03) :431-437
[44]   5-Pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis [J].
Kopka, Klaus ;
Faust, Andreas ;
Keul, Petra ;
Wagner, Stefan ;
Breyholz, Hans-Joerg ;
Hoeltke, Carsten ;
Schober, Otmar ;
Schaefers, Michael ;
Levkau, Bodo .
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (23) :6704-6715
[45]   Radiomics: Extracting more information from medical images using advanced feature analysis [J].
Lambin, Philippe ;
Rios-Velazquez, Emmanuel ;
Leijenaar, Ralph ;
Carvalho, Sara ;
van Stiphout, Ruud G. P. M. ;
Granton, Patrick ;
Zegers, Catharina M. L. ;
Gillies, Robert ;
Boellard, Ronald ;
Dekker, Andre ;
Aerts, Hugo J. W. L. .
EUROPEAN JOURNAL OF CANCER, 2012, 48 (04) :441-446
[46]   A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35 years of the ISRC? [J].
Lapi, Suzanne E. ;
Welch, Michael J. .
NUCLEAR MEDICINE AND BIOLOGY, 2012, 39 (05) :601-608
[47]   A Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging [J].
Lee, Eunsung ;
Kamlet, Adam S. ;
Powers, David C. ;
Neumann, Constanze N. ;
Boursalian, Gregory B. ;
Furuya, Takeru ;
Choi, Daniel C. ;
Hooker, Jacob M. ;
Ritter, Tobias .
SCIENCE, 2011, 334 (6056) :639-642
[48]   In vivo biological activity of the histone deacetylase inhibitor LA0824 is detectable with 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography [J].
Leyton, Julius ;
Alao, John P. ;
Da Costa, Marco ;
Stavropoulou, Alexandra V. ;
Latigo, John R. ;
Perumal, Meg ;
Pillai, Radhakrishna ;
He, Qimin ;
Atadja, Peter ;
Lam, Eric W. -F. ;
Workman, Paul ;
Vigushin, David M. ;
Aboagye, Eric O. .
CANCER RESEARCH, 2006, 66 (15) :7621-7629
[49]   Site-specific labeling of annexin V with F-18 for apoptosis imaging [J].
Li, Xuehe ;
Link, Jeanne M. ;
Stekhova, Svetlana ;
Yagle, Kevin J. ;
Smito, Christina ;
Krohn, Kenneth A. ;
Tait, Jonathan F. .
BIOCONJUGATE CHEMISTRY, 2008, 19 (08) :1684-1688
[50]   Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes [J].
Li, Zibo ;
Cai, Hancheng ;
Hassink, Matthew ;
Blackman, Melissa L. ;
Brown, Richard C. D. ;
Conti, Peter S. ;
Fox, Joseph M. .
CHEMICAL COMMUNICATIONS, 2010, 46 (42) :8043-8045
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