New Frontiers in the Design and Synthesis of Imaging Probes for PET Oncology: Current Challenges and Future Directions

被引：30

作者：

Smith, Graham ^{[2
]}

Carroll, Laurence ^{[1
]}

Aboagye, Eric O. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Comprehens Canc Imaging Ctr, Fac Med, London W12 0NN, England

[2] Univ Hull, Postgrad Med Inst, Kingston Upon Hull HU6 7RX, N Humberside, England

来源：

MOLECULAR IMAGING AND BIOLOGY | 2012年 / 14卷 / 06期

关键词：

Positron emission tomography; Probe development; Therapy monitoring; F-18]FDG; COPPER-FREE CLICK; IN-VITRO; POSITRON; APOPTOSIS; CANCER; HYPOXIA; PROLIFERATION; THERAPY; TUMORS; TRACER;

D O I：

10.1007/s11307-012-0590-y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Despite being developed over 30 years ago, 2-deoxy-2-[F-18]fluoro-d-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.

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收藏

页码：653 / 666

页数：14

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