Anti-TNF-α in the treatment of non-infectious uveitis

被引：3
|
作者：
Hoogewoud, Florence [1 ,2 ]
Kowalczuk, Laura [2 ,3 ]
Bousquet, Elodie [1 ,3 ]
Brezin, Antoine [1 ,3 ]
Touchard, Elodie [4 ]
Buggage, Ronald [4 ]
Bordet, Thierry [4 ]
Behar-Cohen, Francine [1 ,3 ]
机构：
[1] Univ Paris, Ophtalmopole Hop Cochin, Assistance Publ Fopitaux Paris, 27 Rue Faubourg St Jacques, F-75014 Paris, France
[2] Univ Lausanne, Dept Ophtalmol, Hop Ophtalmol Jules Gonin, Lausanne, Switzerland
[3] Univ Paris, Inserm UMR 1138, Physiopathol Malad Oculaires Innovat Therapeut, Ctr Rech Cordeliers, 15 Rue Ecole Med, F-75006 Paris, France
[4] Eyevensys SAS, Paris, France
来源：
M S-MEDECINE SCIENCES | 2020年 / 36卷 / 10期
关键词：
TUMOR-NECROSIS-FACTOR; LONG-TERM EFFICACY; ANTERIOR UVEITIS; ELECTROTRANSFER; ADALIMUMAB; INFLIXIMAB; DELIVERY; PRINCIPLES; THERAPY; FLARES;
D O I：
10.1051/medsci/2020160
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Non-infectious uveitis is a heterogenous group of potentially blinding ocular autoimmune diseases that may represent a manifestation of a systemic condition or may affect the eyes only. A systemically administered anti-TNF has recently been approved for the treatment of non-infectious uveitis, broadening the therapeutic arsenal available to control intraocular inflammation and reduce uveitis complications that can lead to vision loss. When uveitis affects only the eyes, a local anti-TNF-alpha administration strategy could optimize the ocular therapeutic effect and reduce undesirable systemic side-effects. A new ocular method of non-viral gene therapy, currently in development, may broaden the indications for ocular anti-TNF-alpha agents, not only for uveitis but also for other diseases in which TNF-alpha-mediated neuro-inflammation has been demonstrated.
引用
收藏
页码：893 / 899
页数：7
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