Anti-TNF-α in the treatment of non-infectious uveitis

被引：3

作者：

Hoogewoud, Florence ^{[1
,2
]}

Kowalczuk, Laura ^{[2
,3
]}

Bousquet, Elodie ^{[1
,3
]}

Brezin, Antoine ^{[1
,3
]}

Touchard, Elodie ^{[4
]}

Buggage, Ronald ^{[4
]}

Bordet, Thierry ^{[4
]}

Behar-Cohen, Francine ^{[1
,3
]}

机构：

[1] Univ Paris, Ophtalmopole Hop Cochin, Assistance Publ Fopitaux Paris, 27 Rue Faubourg St Jacques, F-75014 Paris, France

[2] Univ Lausanne, Dept Ophtalmol, Hop Ophtalmol Jules Gonin, Lausanne, Switzerland

[3] Univ Paris, Inserm UMR 1138, Physiopathol Malad Oculaires Innovat Therapeut, Ctr Rech Cordeliers, 15 Rue Ecole Med, F-75006 Paris, France

[4] Eyevensys SAS, Paris, France

来源：

M S-MEDECINE SCIENCES | 2020年 / 36卷 / 10期

关键词：

TUMOR-NECROSIS-FACTOR; LONG-TERM EFFICACY; ANTERIOR UVEITIS; ELECTROTRANSFER; ADALIMUMAB; INFLIXIMAB; DELIVERY; PRINCIPLES; THERAPY; FLARES;

D O I：

10.1051/medsci/2020160

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Non-infectious uveitis is a heterogenous group of potentially blinding ocular autoimmune diseases that may represent a manifestation of a systemic condition or may affect the eyes only. A systemically administered anti-TNF has recently been approved for the treatment of non-infectious uveitis, broadening the therapeutic arsenal available to control intraocular inflammation and reduce uveitis complications that can lead to vision loss. When uveitis affects only the eyes, a local anti-TNF-alpha administration strategy could optimize the ocular therapeutic effect and reduce undesirable systemic side-effects. A new ocular method of non-viral gene therapy, currently in development, may broaden the indications for ocular anti-TNF-alpha agents, not only for uveitis but also for other diseases in which TNF-alpha-mediated neuro-inflammation has been demonstrated.

引用

页码：893 / 899

页数：7

共 54 条

[1] Anti-tumor necrosis factor agents in sarcoidosis: A systematic review of efficacy and safety [J].

Adler, Brandon L. ;

Wang, Catherine J. ;

Thanh-Lan Bui ;

Schilperoort, Hannah M. ;

Armstrong, April W. .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2019, 48 (06) :1093-1104

[2] DNA electrotransfer:: its principles and an updated review of its therapeutic applications [J].

André, F ;

Mir, LM .

GENE THERAPY, 2004, 11 (Suppl 1) :S33-S42

[3]

[Anonymous], 2018, Lancet Oncol, V19, pe581

[4] Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma [J].

Bauer, Dirk ;

Kasper, Maren ;

Walscheid, Karoline ;

Koch, Joerg M. ;

Muether, Philipp S. ;

Kirchhof, Bernd ;

Heiligenhaus, Arnd ;

Heinz, Carsten .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[5] Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases [J].

Billmeier, Ulrike ;

Dieterich, Walburga ;

Neurath, Markus F. ;

Atreya, Raja .

WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (42) :9300-9313

[6] Non-viral ocular gene therapy: Potential ocular therapeutic avenues [J].

Bloquel, C. ;

Bourges, J. L. ;

Touchard, E. ;

Berdugo, M. ;

BenEzra, D. ;

Behar-Cohen, F. .

ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (11) :1224-1242

[7] Cytokine Profiling in Aqueous Humor Samples From Patients With Non-Infectious Uveitis Associated With Systemic Inflammatory Diseases [J].

Bonacini, Martina ;

Soriano, Alessandra ;

Cimino, Luca ;

De Simone, Luca ;

Bolletta, Elena ;

Gozzi, Fabrizio ;

Muratore, Francesco ;

Nicastro, Maria ;

Belloni, Lucia ;

Zerbini, Alessandro ;

Fontana, Luigi ;

Salvarani, Carlo ;

Croci, Stefanie .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[8] Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene A Secondary Analysis of a Phase 1/2 Clinical Trial [J].

Bouquet, Celine ;

Clermont, Catherine Vignal ;

Galy, Anne ;

Fitoussi, Serge ;

Blouin, Laure ;

Munk, Marion R. ;

Valero, Sonia ;

Meunier, Sandrine ;

Katz, Barrett ;

Sahel, Jose Alain ;

Thomasson, Nitza .

JAMA OPHTHALMOLOGY, 2019, 137 (04) :399-406

[9] Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept [J].

Braun, J ;

Baraliakos, X ;

Listing, J ;

Sieper, J .

ARTHRITIS AND RHEUMATISM, 2005, 52 (08) :2447-2451

[10]

Brezin AP, 2010, SEMIOLOGIE CLASSIFIC

← 1 2 3 4 5 6 →