Anti-TNF-α in the treatment of non-infectious uveitis

被引：3

作者：

Hoogewoud, Florence ^{[1
,2
]}

Kowalczuk, Laura ^{[2
,3
]}

Bousquet, Elodie ^{[1
,3
]}

Brezin, Antoine ^{[1
,3
]}

Touchard, Elodie ^{[4
]}

Buggage, Ronald ^{[4
]}

Bordet, Thierry ^{[4
]}

Behar-Cohen, Francine ^{[1
,3
]}

机构：

[1] Univ Paris, Ophtalmopole Hop Cochin, Assistance Publ Fopitaux Paris, 27 Rue Faubourg St Jacques, F-75014 Paris, France

[2] Univ Lausanne, Dept Ophtalmol, Hop Ophtalmol Jules Gonin, Lausanne, Switzerland

[3] Univ Paris, Inserm UMR 1138, Physiopathol Malad Oculaires Innovat Therapeut, Ctr Rech Cordeliers, 15 Rue Ecole Med, F-75006 Paris, France

[4] Eyevensys SAS, Paris, France

来源：

M S-MEDECINE SCIENCES | 2020年 / 36卷 / 10期

关键词：

TUMOR-NECROSIS-FACTOR; LONG-TERM EFFICACY; ANTERIOR UVEITIS; ELECTROTRANSFER; ADALIMUMAB; INFLIXIMAB; DELIVERY; PRINCIPLES; THERAPY; FLARES;

D O I：

10.1051/medsci/2020160

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Non-infectious uveitis is a heterogenous group of potentially blinding ocular autoimmune diseases that may represent a manifestation of a systemic condition or may affect the eyes only. A systemically administered anti-TNF has recently been approved for the treatment of non-infectious uveitis, broadening the therapeutic arsenal available to control intraocular inflammation and reduce uveitis complications that can lead to vision loss. When uveitis affects only the eyes, a local anti-TNF-alpha administration strategy could optimize the ocular therapeutic effect and reduce undesirable systemic side-effects. A new ocular method of non-viral gene therapy, currently in development, may broaden the indications for ocular anti-TNF-alpha agents, not only for uveitis but also for other diseases in which TNF-alpha-mediated neuro-inflammation has been demonstrated.

引用

页码：893 / 899

页数：7

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