Porous red cell ultrastructure and loss of membrane asymmetry in a novel case of hemolytic anemia

被引：12

作者：

Banerjee, Debasis ^{[2
]}

Saha, Sutapa ^{[1
]}

Basu, Sumanta ^{[1
]}

Chakrabarti, Abhijit ^{[1
]}

机构：

[1] Saha Inst Nucl Phys, Struct Genom Sect, Kolkata 700064, India

[2] Clin Haematol Serv, Kolkata, India

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2008年 / 81卷 / 05期

关键词：

red cell; membrane asymmetry; porous ultrastructure; microcytosis;

D O I：

10.1111/j.1600-0609.2008.01153.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transmission electron microscopic study revealed large pores on the erythrocyte ghost membranes, disrupted cytoskeleton and microcytosis of circulating erythrocytes in a novel case of hemolytic anemia. Greater loss of phosphatidylserine (PS) asymmetry was observed in younger erythrocytes compared with the aged ones in contrast to the normal red cells. Levels of sialylated glycoconjugates, such as glycophorin, measured by the binding of wheat germ agglutinin, showed greater loss upon aging. Such drastic loss of PS asymmetry leads to faster eryptosis, mediated by shedding of glycophorin-containing microvesicles leaving highly PS-exposed erythrocytes accessible to the phagocytes.

引用

页码：399 / 402

页数：4

共 9 条

[1] Loss of phospholipid membrane asymmetry and sialylated glycoconjugates from erythrocyte surface in haemoglobin E β-thalassaemia [J].