Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans

被引：30
作者：
Sallusto, Federica [1 ,2 ]
Cassotta, Antonino [1 ,2 ]
Hoces, Daniel [1 ]
Foglierini, Mathilde [1 ]
Lanzavecchia, Antonio [1 ]
机构：
[1] Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland
[2] Swiss Fed Inst Technol, Inst Microbiol, CH-8093 Zurich, Switzerland
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2018年 / 10卷 / 03期
关键词：
FUNCTIONAL-HETEROGENEITY; LYMPHOKINE ACTIVITIES; INTERLEUKIN; 22; DIFFERENTIATION; CLONES; LYMPHOCYTES; POPULATIONS; EXPRESSION; T-HELPER-1; PHENOTYPE;
D O I：
10.1101/cshperspect.a029421
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The wide range of effector and memory T cells is instrumental for immune regulation and tailored mechanisms of protection against pathogens. Here, we will focus on human CD4 T cells and discuss T-cell plasticity and intraclonal diversification in the context of a progressive and selective model of CD4 T-cell differentiation.
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页数：8
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