miR-132 Targets FOXA1 and Exerts Tumor-Suppressing Functions in Thyroid Cancer

被引：27

作者：

Chen, Xin ^{[1
]}

Li, Mingzhe ^{[2
]}

Zhou, Hongwei ^{[1
]}

Zhang, Li ^{[1
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Radiol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, China Japan Union Hosp, Changchun, Jilin, Peoples R China

来源：

ONCOLOGY RESEARCH | 2019年 / 27卷 / 04期

关键词：

MicroRNAs; miR-132; Thyroid cancer; FOXA1; CELL-PROLIFERATION; HEPATOCELLULAR-CARCINOMA; MIGRATION; INVASION; MICRORNA-132; EXPRESSION; GROWTH;

D O I：

10.3727/096504018X15201058168730

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNA-132 (niiR-132) has been demonstrated to be a tumor suppressor in several types of tumors. However, the expression and the role of miR-132 in human thyroid cancer are still poorly understood. The aim of the present study was to examine the potential roles and molecular mechanism of miR-132 in thyroid cancer. We found that miR-132 expression levels were significantly downregulated in thyroid cancer tissues and cell lines. Function assays showed that overexpression of miR-132 in TPC1 cells inhibited cell proliferation, migration, and invasion. Forkhead box protein Al (FOXA1) was identified as a direct target of miR-132 in thyroid cancer cells. Knockdown of FOXA1 in TPC1 cells significantly inhibited cell proliferation, migration, and invasion, which mimicked the suppressive effect induced by miR-132 overexpression. Restoration of FOXA1 expression partially reversed the suppressive effect induced by miR-132 overexpression. Taken together, these results suggested that niiR-132 acts as a tumor suppressor in thyroid cancer through targeting FOXA1.

引用

页码：431 / 437

页数：7

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