Clinical utility of RASSF1A methylation in human malignancies

被引：99
作者：
Grawenda, A. M. [1 ]
O'Neill, E. [1 ]
机构：
[1] Univ Oxford, Dept Oncol, CRUK MRC Oxford Inst, Oxford, England
来源：
BRITISH JOURNAL OF CANCER | 2015年 / 113卷 / 03期
关键词：
RASSF1A; hippo pathway; gene methylation; cancer; biomaker; ABERRANT PROMOTER METHYLATION; CELL LUNG-CANCER; FREQUENT EPIGENETIC INACTIVATION; CPG ISLAND HYPERMETHYLATION; TUMOR-SUPPRESSOR GENES; LYMPH-NODE METASTASIS; BREAST-CANCER; DNA METHYLATION; POOR-PROGNOSIS; STAGE-I;
D O I：
10.1038/bjc.2015.221
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The high frequency of RASSF1A methylation has been noted in a vast number of patients in a broad spectrum of malignancies, suggesting that RASSF1A inactivation is associated with cancer pathogenesis. However, whether this recurrent incidence of RASSF1A hypermethylation in human malignancies and its association with more aggressive tumour phenotype is a frequent event across different cancer types has not yet been discussed. In this review, we interrogated existing evidence for association of RASSF1A hypermethylation with clinicopathological characteristics that can indicate more invasive lesions.
引用
收藏
页码：372 / 381
页数：10
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