Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

被引：41

作者：

Aylwin, Carlos F. ^{[1
]}

Toro, Carlos A. ^{[1
]}

Shirtcliff, Elizabeth ^{[2
]}

Lomniczi, Alejandro ^{[1
]}

机构：

[1] OHSU, Oregon Natl Primate Res Ctr, Beaverton, OR USA

[2] Iowa State Univ, Ames, IA USA

来源：

JOURNAL OF RESEARCH ON ADOLESCENCE | 2019年 / 29卷 / 01期

关键词：

GONADOTROPIN-RELEASING-HORMONE; GENOME-WIDE ASSOCIATION; ESTROGEN-RECEPTOR-ALPHA; GROWTH-FACTOR-I; REPRODUCTION PHYSIOLOGICAL ROLES; CENTRAL PRECOCIOUS PUBERTY; MAMMALIAN CIRCADIAN CLOCK; CELL-ADHESION MOLECULE; SEX-DIFFERENCES; ARCUATE NUCLEUS;

D O I：

10.1111/jora.12385

中图分类号：

D669 [社会生活与社会问题]; C913 [社会生活与社会问题];

学科分类号：

1204 ;

摘要：

The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.

引用

页码：54 / 79

页数：26

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