Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

被引：41

作者：

Aylwin, Carlos F. ^{[1
]}

Toro, Carlos A. ^{[1
]}

Shirtcliff, Elizabeth ^{[2
]}

Lomniczi, Alejandro ^{[1
]}

机构：

[1] OHSU, Oregon Natl Primate Res Ctr, Beaverton, OR USA

[2] Iowa State Univ, Ames, IA USA

来源：

JOURNAL OF RESEARCH ON ADOLESCENCE | 2019年 / 29卷 / 01期

关键词：

GONADOTROPIN-RELEASING-HORMONE; GENOME-WIDE ASSOCIATION; ESTROGEN-RECEPTOR-ALPHA; GROWTH-FACTOR-I; REPRODUCTION PHYSIOLOGICAL ROLES; CENTRAL PRECOCIOUS PUBERTY; MAMMALIAN CIRCADIAN CLOCK; CELL-ADHESION MOLECULE; SEX-DIFFERENCES; ARCUATE NUCLEUS;

D O I：

10.1111/jora.12385

中图分类号：

D669 [社会生活与社会问题]; C913 [社会生活与社会问题];

学科分类号：

1204 ;

摘要：

The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.

引用

页码：54 / 79

页数：26

共 243 条

[11]

Archer T, 2013, J Genet Syndr Gene Ther, V4

[12] Adrenarche - physiology, biochemistry and human disease [J].

Auchus, RJ ;

Rainey, WE .

CLINICAL ENDOCRINOLOGY, 2004, 60 (03) :288-296

[13] Epigenetic control of vasopressin expression is maintained by steroid hormones in the adult male rat brain [J].

Auger, Catherine J. ;

Coss, Dylan ;

Auger, Anthony P. ;

Forbes-Lorman, Robin M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (10) :4242-4247

[14] The Physiological Role of Arcuate Kisspeptin Neurons in the Control of Reproductive Function in Female Rats [J].

Beale, K. E. ;

Kinsey-Jones, J. S. ;

Gardiner, J. V. ;

Harrison, E. K. ;

Thompson, E. L. ;

Hu, M. H. ;

Sleeth, M. L. ;

Sam, A. H. ;

Greenwood, H. C. ;

McGavigan, A. K. ;

Dhillo, W. S. ;

Mora, J. M. ;

Li, X. F. ;

Franks, S. ;

Bloom, S. R. ;

O'Byrne, K. T. ;

Murphy, K. G. .

ENDOCRINOLOGY, 2014, 155 (03) :1091-1098

[15] Mutations in the human gonadotropin-releasing hormone receptor: Insights into receptor biology and function [J].

Bedecarrats, Grgoy Y. ;

Kaiser, Ursula B. .

SEMINARS IN REPRODUCTIVE MEDICINE, 2007, 25 (05) :368-378

[16] Mammalian circadian clock and metabolism - the epigenetic link [J].

Bellet, Marina Maria ;

Sassone-Corsi, Paolo .

JOURNAL OF CELL SCIENCE, 2010, 123 (22) :3837-3848

[17] The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism [J].

Bianco, Suzy D. C. ;

Kaiser, Ursula B. .

NATURE REVIEWS ENDOCRINOLOGY, 2009, 5 (10) :569-576

[18] SYNCHRONIZATION OF AUGMENTED LUTEINIZING-HORMONE SECRETION WITH SLEEP DURING PUBERTY [J].

BOYAR, R ;

ROFFWARG, H ;

WEITZMAN, E ;

FINKELSTEIN, J ;

KAPEN, S ;

HELLMAN, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1972, 287 (12) :582-+

[19] Central effects of estradiol in the regulation of food intake, body weight, and adiposity [J].

Brown, L. M. ;

Clegg, D. J. .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2010, 122 (1-3) :65-73

[20] SALIVARY TESTOSTERONE LEVELS AND THE PROGRESS OF PUBERTY IN THE NORMAL BOY [J].

BUTLER, GE ;

WALKER, RF ;

WALKER, RV ;

TEAGUE, P ;

RIADFAHMY, D ;

RATCLIFFE, SG .

CLINICAL ENDOCRINOLOGY, 1989, 30 (05) :587-596

← 1 2 3 4 5 6 7 8 9 10 →