The Involvement of the Dopaminergic Midbrain and Cortico-Striatal-Thalamic Circuits in the Integration of Reward Prospect and Attentional Task Demands

被引:159
作者
Krebs, Ruth M. [1 ,2 ]
Boehler, Carsten N. [1 ,2 ]
Roberts, Kenneth C. [2 ]
Song, Allen W. [3 ]
Woldorff, Marty G. [2 ,4 ]
机构
[1] Univ Ghent, Dept Expt Psychol, B-9000 Ghent, Belgium
[2] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA
[3] Duke Univ, Brain Imaging & Anal Ctr, Durham, NC 27708 USA
[4] Duke Univ, Dept Psychiat, Durham, NC 27708 USA
基金
美国国家卫生研究院;
关键词
attention; fMRI; midbrain; reward; task demands; COGNITIVE CONTROL; DECISION-MAKING; MONETARY REWARD; ACTIVATION; NETWORK; CORTEX; REGIONS; RESPONSES; ANTICIPATION; CINGULATE;
D O I
10.1093/cercor/bhr134
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Reward has been shown to promote human performance in multiple task domains. However, an important debate has developed about the uniqueness of reward-related neural signatures associated with such facilitation, as similar neural patterns can be triggered by increased attentional focus independent of reward. Here, we used functional magnetic resonance imaging to directly investigate the neural commonalities and interactions between the anticipation of both reward and task difficulty, by independently manipulating these factors in a cued-attention paradigm. In preparation for the target stimulus, both factors increased activity within the midbrain, dorsal striatum, and fronto-parietal areas, while inducing deactivations in default-mode regions. Additionally, reward engaged the ventral striatum, posterior cingulate, and occipital cortex, while difficulty engaged medial and dorsolateral frontal regions. Importantly, a network comprising the midbrain, caudate nucleus, thalamus, and anterior midcingulate cortex exhibited an interaction between reward and difficulty, presumably reflecting additional resource recruitment for demanding tasks with profitable outcome. This notion was consistent with a negative correlation between cue-related midbrain activity and difficulty-induced performance detriments in reward-predictive trials. Together, the data demonstrate that expected value and attentional demands are integrated in cortico-striatal-thalamic circuits in coordination with the dopaminergic midbrain to flexibly modulate resource allocation for an effective pursuit of behavioral goals.
引用
收藏
页码:607 / 615
页数:9
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