Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease

被引：126

作者：

Murrell, Wayne ^{[1
]}

Wetzig, Andrew ^{[1
]}

Donnellan, Michael ^{[1
]}

Feron, Francois ^{[2
,3
]}

Burne, Tom ^{[1
,4
]}

Meedeniya, Adrian ^{[1
]}

Kesby, James ^{[4
]}

Bianco, John ^{[1
]}

Perry, Chris ^{[5
]}

Silburn, Peter ^{[1
,6
]}

Mackay-Sim, Alan ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Natl Ctr Adult Stem Cell Res, Brisbane, Qld 4111, Australia

[2] Univ Mediterranee, CNRS, NICN, IFR Jean Roche,UMR6184, Marseille, France

[3] Univ Mediterranee, AP HM Inst Paoli Calmettes, INSERM, CIC B 150,Ctr Invest Clin Biotherapie, Marseille, France

[4] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia

[5] Princess Alexandra Hosp, Dept Otolaryngol, Brisbane, Qld 4102, Australia

[6] Univ Queensland, Sch Med, Brisbane, Qld, Australia

来源：

STEM CELLS | 2008年 / 26卷 / 08期

关键词：

Parkinson's disease; olfactory stem cell; autologous cell therapy; dopaminergic;

D O I：

10.1634/stemcells.2008-0074

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Parkinson's disease is a complex disorder characterized by degeneration of dopaminergic neurons in the substantia nigra in the brain. Stem cell transplantation is aimed at replacing dopaminergic neurons because the most successful drug therapies affect these neurons and their synaptic targets. We show here that neural progenitors can be grown from the olfactory organ of humans, including those with Parkinson's disease. These neural progenitors proliferated and generated dopami- nergic cells in vitro. They also generated clopaminergic cells when transplanted into the brain and reduced the behavioral asymmetry induced by ablation of the dopaminergic neurons in the rat model of Parkinson's disease. Our results indicate that Parkinson's patients could provide their own source of neuronal progenitors for cell transplantation therapies and for direct investigation of the biology and treatments of Parkinson's disease.

引用

页码：2183 / 2192

页数：10

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