Therapeutic strategies in ischemic cardiomyopathy: Focus on mitochondria! quality surveillance

被引：69

作者：

Chang, Xing ^{[1
]}

Toan, Sam ^{[2
]}

Li, Ruibing ^{[3
]}

Zhou, Hao ^{[4
]}

机构：

[1] Chinese Acad Tradit Chinese Med, Guanganmen Hosp, Beijing, Peoples R China

[2] Univ Minnesota, Dept Chem Engn, Duluth, MN 55812 USA

[3] Chinese Peoples Liberat Army, Med Sch, Med Ctr 1, Dept Clin Lab Med, Beijing, Peoples R China

[4] Peoples Liberat Army Gen Hosp, Med Ctr 6, Dept Cardiol, Beijing 100048, Peoples R China

来源：

EBIOMEDICINE | 2022年 / 84卷

关键词：

Ischemic cardiomyopathy; Mitochondrial quality surveillance; Cardiomyocyte; Mitochondrial dynamics; Mitophagy; Mitochondrial biogenesis; MITOPHAGY; DYNAMICS; FISSION; FUSION; HEART; CARDIOPROTECTION; DYSFUNCTION; TOLERANCE; PROTEINS; DOMAIN;

D O I：

10.1016/j.ebiom.2022.104260

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite considerable efforts to prevent and treat ischemic cardiomyopathy (ICM), effective therapies remain lacking, in part owing to the complexity of the underlying molecular mechanisms, which are not completely understood yet. It is now widely thought that mitochondria serve as "sentinel" organelles that are capable of detecting cellular injury and integrating multiple stress signals. These pathophysiological activities are temporally and spatially governed by the mitochondrial quality surveillance (MQS) system, involving mitochondrial dynamics, mitophagy, and biogenesis. Dysregulation of MQS is an early and critical process contributing to mitochondrial bioenergetic dysfunction and sublethal injury to cardiomyocytes during ICM. An improved understanding of the pathogenesis of ICM may enable the development of novel preventive and therapeutic strategies aimed at overcoming the challenge of myocardial ischemia and its cardiovascular sequelae. This review describes recent research on the protective effects of MQS in ICM and highlights promising therapeutic targets. Copyright (C) 2022 The Authors. Published by Elsevier B.V.

引用

页数：13