Protein modification and maintenance systems as biomarkers of ageing

被引：36

作者：

Vanhooren, Valerie ^{[1
,7
]}

Santos, Alexander Navarrete ^{[2
]}

Voutetakis, Konstantinos ^{[3
]}

Petropoulos, Isabelle ^{[4
,5
,6
]}

Libert, Claude ^{[1
,7
]}

Simm, Andreas ^{[2
]}

Gonos, Efstathios S. ^{[3
]}

Friguet, Bertrand ^{[1
,4
,5
,6
]}

机构：

[1] Univ Ghent, Dept Mol Biol, B-9052 Ghent, Belgium

[2] Univ Halle Wittenberg, Dept Cardiothorac Surg, D-06120 Halle, Germany

[3] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens 11635, Greece

[4] Univ Paris 06, Sorbonne Univ, UMR Biol Adaptat & Ageing IBPS 8256, F-75005 Paris, France

[5] CNRS, UMR 8256, F-75005 Paris, France

[6] INSERM, U1164, F-75005 Paris, France

[7] VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2015年 / 151卷

关键词：

Ageing; Biomarkers; Protein modification; Protein maintenance; METHIONINE-SULFOXIDE-REDUCTASE; GLYCATION END-PRODUCTS; HIGH-DENSITY-LIPOPROTEIN; UBIQUITIN-PROTEASOME PATHWAY; HUMAN EMBRYONIC FIBROBLASTS; TYPE-2; DIABETES-MELLITUS; GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; HUMAN BJ FIBROBLASTS; LIFE-SPAN EXTENSION;

D O I：

10.1016/j.mad.2015.03.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing. Within the frame of the Mark-Age project, the workpackage dedicated to "markers based on proteins and their modifications" has been firstly focused on enzymatic and non-enzymatic post-translational modifications of serum proteins by carbohydrates. The second focus of the workpackage has been directed towards protein maintenance systems that are involved either in protein quality control (ApoJ/Clusterin) or in the removal of oxidatively damaged proteins through degradation and repair (proteasome and methionine sulfoxide reductase systems). This review describes the most relevant features of these protein modifications and maintenance systems, their fate during ageing and/or their implication in ageing and longevity. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：71 / 84

页数：14

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