Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid

被引：161
作者：
Anderson, Elizabeth A.
Isaacman, Steven
Peabody, David S.
Wang, Edwin Y.
Canary, James W.
Kirshenbaum, Kent
机构：
[1] NYU, Dept Chem, New York, NY 10003 USA
[2] NYU, Dept Radiol, Sch Med, New York, NY 10016 USA
[3] Univ New Mexico, Hlth Sci Ctr, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA
来源：
NANO LETTERS | 2006年 / 6卷 / 06期
关键词：
D O I：
10.1021/nl060378g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of paramagnetic centers and slow tumbling rate of modified MS2 capsids provided enhanced T-1 relaxivities up to 7200 mM(-1) s(-1) per particle. A bimodal imaging agent was generated by sequential conjugation of fluorescein and Gd3+ chelate. These results illustrate the potential for engineering natural protein assemblies to address bionanotechnology applications.
引用
收藏
页码：1160 / 1164
页数：5
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