Tandem bispecific broadly neutralizing antibody - a novel approach to HIV-1 treatment

被引：2

作者：

Ferrari, Guido ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2018年 / 128卷 / 06期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; MONOCLONAL-ANTIBODIES; RHESUS-MONKEYS; CD4; BINDING; POTENT; MACAQUES; VIREMIA; PROTECTION; RESERVOIRS; CHALLENGE;

D O I：

10.1172/JCI121078

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The last decade has led to a significant advance in our knowledge of HIV-1 latency and immunity. However, we are still not close to finding a cure for HIV-1. Although combination antiretroviral therapy (cART) has led to increased survival, almost close to that of the general population, it is still not curative. In the current issue of the JCI, Wu et al. studied the prophylactic and therapeutic potential of an engineered tandem bispecific broadly neutralizing antibody (bs-bnAb), BiIA-SG. This bnAb's breadth and potency were highly effective in protection and treatment settings, as measured by complete viremia control following direct infusion, as well as elimination of infected cells and delay in viral rebound when delivered with a recombinant vector. These observations underscore the need for the clinical development of BiIA-SG for the prevention of HIV-1.

引用

页码：2189 / 2191

页数：3

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