Mesoporous Silica Nanoparticles as a Nanocarrier for Delivery of Vitamin C

被引:18
作者
Rashidi, Ladan [1 ]
Vasheghani-Farahani, Ebrahim [1 ]
Rostami, Khosrow [2 ]
Gangi, Fariba [1 ]
Fallahpour, Masoud [2 ]
机构
[1] Tarbiat Modares Univ, Div Biotechnol, Dept Chem Engn, Tehran, Iran
[2] IROST, Ctr Biotechnol, Tehran, Iran
关键词
Ascorbic Acid; Mesoporous Silica; Nanoparticles; Release; Vitamin C; ASCORBIC-ACID; CONTROLLED-RELEASE; DRUG-DELIVERY; CANCER; MARKERS; CELLS;
D O I
10.5812/ijb.14279
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: In the last decades, mesoporous silica nanoparticles (MSNs) are improved for drug delivery, imaging, and biomedical applications due to their special properties such as large surface area, high drug loading capacity, tunable pore size, and modification of surface area by functional groups. Objectives: The aim of this study was to evaluate MSNs as carriers for oral colon-specific and human plasma blood delivery of vitamin C. Materials and Methods: In this work, mesoporous silica nanoparticles were synthesized and characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and N2- adsorption. Then MSNs were loaded by L-ascorbic acid (AscH 2), and the release of L-ascorbic acid from AscH 2-MSNs into the simulated fluids in different pHs was investigated, including simulated gastric fluid (SGF, pH, 1.2), simulated intestinal fluid (SIF, pH, 6.8), and simulated body fluid (SBF, pH, 7.4). The amount of loaded AscH 2 into the MSNs was determined by thermal gravimetric analysis (TGA). Results: Synthesized MSNs were spheres and the average diameter of them was 100 +/- 9 nm. Results showed that about 567.8 nanomole of vitamin C. It was found that the burst release of AscH 2 into SGF was slower than SIF and SBF. Conclusions: The rate of AscH 2 release from the nanoparticles into alkaline solutions was faster than acidic solutions because of electrostatic interactions between vitamin C and MSNs surface. The loading amount of Vitamin C was dependent on the surface of chemical moiety of MSNs and the steric effects of vitamin C structure.
引用
收藏
页码:209 / 213
页数:5
相关论文
共 22 条
[1]   Intravenous Ascorbic Acid Infusion Improves Myocardial Perfusion Grade During Elective Percutaneous Coronary Intervention Relationship With Oxidative Stress Markers [J].
Basili, Stefania ;
Tanzilli, Gaetano ;
Mangieri, Enrico ;
Raparelli, Valeria ;
Di Santo, Serena ;
Pignatelli, Pasquale ;
Violi, Francesco .
JACC-CARDIOVASCULAR INTERVENTIONS, 2010, 3 (02) :221-229
[2]   Controlled release of vitamin B2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings [J].
Bernardos, Andrea ;
Aznar, Elena ;
Coll, Carmen ;
Martinez-Manez, Ramon ;
Manuel Barat, Jose ;
Dolores Marcos, Ma. ;
Sancenon, Felix ;
Benito, Angel ;
Soto, Juan .
JOURNAL OF CONTROLLED RELEASE, 2008, 131 (03) :181-189
[3]   Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues [J].
Chen, Q ;
Espey, MG ;
Krishna, MC ;
Mitchell, JB ;
Corpe, CP ;
Buettner, GR ;
Shacter, E ;
Levine, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (38) :13604-13609
[4]   Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice [J].
Chen, Qi ;
Espey, Michael Graham ;
Sun, Andrew Y. ;
Pooput, Chaya ;
Kirk, Kenneth L. ;
Krishna, Murali C. ;
Khosh, Deena Senecla ;
Drisko, Jeanne ;
Levine, Mark .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (32) :11105-11109
[5]   Mechanised nanoparticles for drug delivery [J].
Coti, Karla K. ;
Belowich, Matthew E. ;
Liong, Monty ;
Ambrogio, Michael W. ;
Lau, Yuen A. ;
Khatib, Hussam A. ;
Zink, Jeffrey I. ;
Khashab, Niveen M. ;
Stoddart, J. Fraser .
NANOSCALE, 2009, 1 (01) :16-39
[6]   Ascorbic acid: Chemistry, biology and the treatment of cancer [J].
Du, Juan ;
Cullen, Joseph J. ;
Buettner, Garry R. .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1826 (02) :443-457
[7]   The new US dietary reference intakes for vitamins C and E [J].
Frei, B ;
Traber, MG .
REDOX REPORT, 2001, 6 (01) :5-9
[8]   BIOAVAILABILITY OF DIETARY IRON IN MAN [J].
HALLBERG, L .
ANNUAL REVIEW OF NUTRITION, 1981, 1 :123-147
[9]   METAL ION AND METAL CHELATE CATALYZED OXIDATION OF ASCORBIC ACID BY MOLECULAR OXYGEN .2. CUPRIC AND FERRIC CHELATE CATALYZED OXIDATION [J].
KHAN, MMT ;
MARTELL, AE .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (26) :7104-&
[10]   Near-Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution [J].
Lee, Chia-Hung ;
Cheng, Shih-Hsun ;
Wang, Yujing ;
Chen, Yu-Ching ;
Chen, Nai-Tzu ;
Souris, Jeffrey ;
Chen, Chin-Tu ;
Mou, Chung-Yuan ;
Yang, Chung-Shi ;
Lo, Leu-Wei .
ADVANCED FUNCTIONAL MATERIALS, 2009, 19 (02) :215-222