Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development

被引：67

作者：

Oldekamp, J

Krämer, N

Alvarez-Bolado, G

Skutella, T

机构：

[1] AG Skutella, Neurosci Res Ctr, D-10117 Berlin, Germany

[2] Max Planck Inst, D-30625 Hannover, Germany

[3] Inst Anat, Dept Expt Embryol, Tissue Engn Div, D-72074 Tubingen, Germany

来源：

GENE EXPRESSION PATTERNS | 2004年 / 4卷 / 03期

关键词：

axonal guidance brain; cochlear epithelium; cranial nerve ganglia; dorsal root ganglia; lung; marker; myocardium; neuroepithelium; pancreas; striated muscle;

D O I：

10.1016/j.modgep.2003.11.008

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have characterized for the first time the mouse expression patterns of the three known members of the novel RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C) by in situ hybridization. Both RGM A and B are mostly expressed in central nervous systems while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system. During development, both RGM A and B appear also in lung and in limb cartilage, while RGM B has additional expression domains in pancreas. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：283 / 288

页数：6