Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression

被引：28
作者：
Mondello, Patrizia [1 ,3 ]
Cuzzocrea, Salvatore [2 ]
Navarra, Michele [2 ,4 ]
Mian, Michael [5 ]
机构：
[1] Univ Messina, Dept Human Pathol, Messina, Italy
[2] Univ Messina, Dept Chem, Biol, Pharmaceut & Environm Sci, Messina, Italy
[3] Mem Sloan Kettering Canc Ctr, Lymphoma Serv, New York, NY USA
[4] Hosp Bolzano, Dept Hematol & Ctr Bone Marrow Transplantat, Bolzano, Italy
[5] Med Univ Innsbruck, Dept Internal Med, Hematol Oncol, Innsbruck, Austria
来源：
ONCOTARGET | 2017年 / 8卷 / 12期
关键词：
multiple myeloma; micro-environment; therapeutic opportunities; osteoclast activation; angiogenesis; ENDOTHELIAL GROWTH-FACTOR; SOLUBLE INTERLEUKIN-6 RECEPTOR; FACTOR-KAPPA-B; MATRIX-METALLOPROTEINASE INHIBITOR; MESENCHYMAL STROMAL CELLS; PREDICTS POOR-PROGNOSIS; SKELETAL-RELATED EVENTS; MULTIPLE-MYELOMA; HUMAN CD38; ZOLEDRONIC ACID;
D O I：
10.18632/oncotarget.14610
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite the advent of many therapeutic agents, such as bortezomib and lenalidomide that have significantly improved the overall survival, multiple myeloma remains an incurable disease. Failure to cure is multifactorial and can be attributed to the underlying genetic heterogeneity of the cancer and to the surrounding micro-environment. Understanding the mutual interaction between myeloma cells and micro-environment may lead to the development of novel treatment strategies able to eradicate this disease. In this review we discuss the principal molecules involved in the micro-environment network in multiple myeloma and the currently available therapies targeting them.
引用
收藏
页码：20394 / 20409
页数：16
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