Increase of EEG Spectral Theta Power Indicates Higher Risk of the Development of Severe Cognitive Decline in Parkinson's Disease after 3 Years

被引：24
作者：
Cozac, Vitalii V. [1 ]
Chaturvedi, Menorca [1 ,2 ]
Hatz, Florian [1 ]
Meyer, Antonia [1 ]
Fuhr, Peter [1 ]
Gschwandtner, Ute [1 ]
机构：
[1] Univ Basel Hosp, Dept Neurol, Basel, Switzerland
[2] Univ Basel, Dept Math & Comp Sci, Basel, Switzerland
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2016年 / 8卷
基金：
瑞士国家科学基金会;
关键词：
EEG; cognitive tests; Parkinson's disease; cognitive decline; cohort study; QUANTITATIVE EEG; ALZHEIMERS-DISEASE; DEMENTIA; IMPAIRMENT;
D O I：
10.3389/fnagi.2016.00284
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Objective: We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson's disease. Methods: We prospectively investigated 37 patients with Parkinson's disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at follow-up. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables [global relative median power (GRMP) spectra] were obtained by a fully automated processing of high-resolution EEG (256-channels). We used linear regression models with calculation of the explained variance to evaluate the relation of baseline parameters with cognitive deterioration. Results: The following baseline parameters significantly predicted severe cognitive decline: GRMP theta (4-8 Hz), cognitive task performance in executive functions and working memory. Conclusions: Combination of neurocognitive tests and qEEG improves identification of patients with higher risk of cognitive decline in PD.
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页数：7
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